Literature DB >> 7067583

Effect of an opiate antagonist (naloxone) on the gastric acid secretory response to sham feeding, pentagastrin, and histamine in man.

M Feldman, Y M Cowley.   

Abstract

We studied the effect of the opiate antagonist naloxone on the human gastric acid secretory response to three secretory stimulants: sham feeding, pentagastrin, and histamine. Intravenous naloxone (40 micrograms/kg/hr) significantly inhibited the acid secretory response to sham feeding without affecting the serum gastrin response to sham feeding. Naloxone also significantly reduced pentagastrin- and histamine-stimulated acid secretion. These studies indicate that naloxone reduces acid secretion in response to all stimulants of acid secretion yet tested in humans.

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Year:  1982        PMID： 7067583     DOI： 10.1007/bf01296749

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  12 in total

1.  USE OF WRITHING TEST FOR EVALUATING ANALGESIC ACTIVITY OF NARCOTIC ANTAGONISTS.

Authors:  H BLUMBERG; P S WOLF; H B DAYTON
Journal:  Proc Soc Exp Biol Med       Date:  1965-03

2.  Studies on the role of cephalic-vagal stimulation in the acid secretory response to eating in normal human subjects.

Authors:  C T Richardson; J H Walsh; K A Cooper; M Feldman; J S Fordtran
Journal:  J Clin Invest       Date:  1977-08       Impact factor: 14.808

3.  Multiple opiate receptor sites on primary afferent fibres.

Authors:  H L Fields; P C Emson; B K Leigh; R F Gilbert; L L Iversen
Journal:  Nature       Date:  1980-03-27       Impact factor: 49.962

4.  Endogenous opioid peptides: multiple agonists and receptors.

Authors:  J A Lord; A A Waterfield; J Hughes; H W Kosterlitz
Journal:  Nature       Date:  1977-06-09       Impact factor: 49.962

5.  Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone).

Authors:  H W Kosterlitz; A J Watt
Journal:  Br J Pharmacol Chemother       Date:  1968-06

6.  Comparison of methionine-enkephalin and morphine in the stimulation of gastric acid secretion in the dog.

Authors:  S J Konturek; J Tasler; M Cieszkowski; E Mikoś; D H Coy; A V Schally
Journal:  Gastroenterology       Date:  1980-02       Impact factor: 22.682

7.  The human pharmacology and abuse potential of N-allylnoroxymorphone (naloxone).

Authors:  D R Jasinski; W R Martin; C A Haertzen
Journal:  J Pharmacol Exp Ther       Date:  1967-08       Impact factor: 4.030

8.  Naloxone.

Authors:  W R Martin
Journal:  Ann Intern Med       Date:  1976-12       Impact factor: 25.391

9.  Effect of naloxone and morphine on gastric acid secretion and on serum gastrin and pancreatic polypeptide concentrations in humans.

Authors:  M Feldman; J H Walsh; I L Taylor
Journal:  Gastroenterology       Date:  1980-08       Impact factor: 22.682

10.  Enkephalin-like immunoreactivity in the human gastrointestinal tract.

Authors:  J M Polak; S R Bloom; S N Sullivan; P Facer; A G Pearse
Journal:  Lancet       Date:  1977-05-07       Impact factor: 79.321
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  2 in total

1.  Effect of acupuncture on gastric acid secretion in healthy male volunteers.

Authors:  G Tougas; L Y Yuan; J W Radamaker; S G Chiverton; R H Hunt
Journal:  Dig Dis Sci       Date:  1992-10       Impact factor: 3.199

2.  On the possible role of different endogenous opiate receptors in gastroduodenal ulceration of the rat.

Authors:  G A Balint; J Nafradi
Journal:  Agents Actions       Date:  1990-08
  2 in total

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