In vitro inactivation of silver sulphadiazine by the addition of cerium salts.

Silver sulphadiazine, with and without cerium salts, was tested in an in vitro topical antimicrobial susceptibility test assay for antimicrobial activity against microorganisms isolated from burn wounds. Compared to silver sulphadiazine alone the addition of cerium to silver sulphadiazine generally reduced the diameter of the antimicrobial inhibitory zones around susceptible organisms. In addition, complete nullification of the activity of silver sulphadiazine occurred in many instances.