Literature DB >> 7066463

Modelling of sustained release of water-soluble drugs from porous, hydrophobic polymers.

R Gurny, E Doelker, N A Peppas.   

Abstract

The release behaviour of water-soluble drugs from hydrophobic, porous polymeric matrices is complicated by the dissolution of the drug in the water-filled pores under quiescent conditions. Mathematical models are presented for drug release above and below the solubility limit of the drug in the dissolution medium, for constant void fraction (porosity). Experimental studies of KCl release from the porous ethyl cellulose tablets in water at 37 degrees C are explained in terms of dissolution-controlled and diffusion-controlled steps of the release mechanism.

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Year:  1982        PMID： 7066463     DOI： 10.1016/0142-9612(82)90057-6

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  13 in total

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2.  Novel/conceptual floating pulsatile system using high internal phase emulsion based porous material intended for chronotherapy.

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4.  Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug.

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5.  Porous carriers for controlled/modulated drug delivery.

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Journal:  Indian J Pharm Sci       Date:  2009-11       Impact factor: 0.975

6.  Controlled release of theophylline monohydrate from amylodextrin tablets: in vitro observations.

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Journal:  Pharm Res       Date:  1994-04       Impact factor: 4.200

7.  Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies.

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8.  Design and development of intraocular polymeric implant systems for long-term controlled-release of clindamycin phosphate for toxoplasmic retinochoroiditis.

Authors:  Lana Tamaddon; S Abolfazl Mostafavi; Reza Karkhane; Mohammad Riazi-Esfahani; Farid Abedin Dorkoosh; Morteza Rafiee-Tehrani
Journal:  Adv Biomed Res       Date:  2015-01-30

9.  Pharmaceutical Evaluation of Cefuroxime Axetil Tablets Available in Drug Market of Pakistan.

Authors:  F Israr; Z A Mahmood; F Hassan; S M F Hasan
Journal:  Indian J Pharm Sci       Date:  2016 Jan-Feb       Impact factor: 0.975

10.  Zn(2+) release behavior and surface characteristics of Zn/LDPE nanocomposites and ZnO/LDPE nanocomposites in simulated uterine solution.

Authors:  Zhihong Yang; Changsheng Xie; Xianping Xia; Shuizhou Cai
Journal:  J Mater Sci Mater Med       Date:  2008-05-22       Impact factor: 4.727
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