Literature DB >> 7066367

Sterol composition of bovine retinal rod outer segment membranes and whole retinas.

S J Fliesler, G J Schroepfer.   

Abstract

The sterol composition of bovine retinal rod outer segment membranes and whole retinas was studied by detailed chromatographic analyses. Cholesterol represented at least 98% of the total 3 beta-monohydroxy sterols of rod outer segment membranes, accounting for 1.68 +/- 0.15% of the dry weight. Whole retinas contained 1.76 +/- 0.29% cholesterol by dry weight, representing at least 99% of the total 3 beta-monohydroxy sterols. Trace amounts of a component having the chromatographic properties of 5 alpha-cholestan-3 beta-ol were found in rod outer segment membranes and whole retinas. Very small amounts of a component having the chromatographic properties of 5 alpha-cholest-7-en-3 beta-ol were found in whole retinas, but not in rod outer segment membranes. The molar ratio of cholesterol to rhodopsin in bovine rod outer segment membranes was approximately 4.7. Cholesterol accounted for only 5-7 mol% of total rod outer segment membrane lipids.

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Year:  1982        PMID： 7066367     DOI： 10.1016/0005-2760(82)90020-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  11 in total

1.  Relationship of cholesterol content to spatial distribution and age of disc membranes in retinal rod outer segments.

Authors:  K Boesze-Battaglia; S J Fliesler; A D Albert
Journal:  J Biol Chem       Date:  1990-11-05       Impact factor: 5.157

Review 2.  The ins and outs of cholesterol in the vertebrate retina.

Authors:  Steven J Fliesler; Lionel Bretillon
Journal:  J Lipid Res       Date:  2010-09-22       Impact factor: 5.922

Review 3.  The role of cholesterol in rod outer segment membranes.

Authors:  Arlene D Albert; Kathleen Boesze-Battaglia
Journal:  Prog Lipid Res       Date:  2005-03-09       Impact factor: 16.195

4.  Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.

Authors:  Aicha Saadane; Natalia Mast; Casey D Charvet; Saida Omarova; Wenchao Zheng; Suber S Huang; Timothy S Kern; Neal S Peachey; Irina A Pikuleva
Journal:  Am J Pathol       Date:  2014-07-25       Impact factor: 4.307

5.  An inducible amphipathic helix within the intrinsically disordered C terminus can participate in membrane curvature generation by peripherin-2/rds.

Authors:  Michelle L Milstein; Victoria A Kimler; Chiranjib Ghatak; Alexey S Ladokhin; Andrew F X Goldberg
Journal:  J Biol Chem       Date:  2017-03-21       Impact factor: 5.157

6.  Membrane curvature generation by a C-terminal amphipathic helix in peripherin-2/rds, a tetraspanin required for photoreceptor sensory cilium morphogenesis.

Authors:  Nidhi Khattree; Linda M Ritter; Andrew F X Goldberg
Journal:  J Cell Sci       Date:  2013-07-25       Impact factor: 5.285

7.  Cholesterol heterogeneity in bovine rod outer segment disk membranes.

Authors:  K Boesze-Battaglia; T Hennessey; A D Albert
Journal:  J Biol Chem       Date:  1989-05-15       Impact factor: 5.157

Review 8.  Molecular basis for photoreceptor outer segment architecture.

Authors:  Andrew F X Goldberg; Orson L Moritz; David S Williams
Journal:  Prog Retin Eye Res       Date:  2016-06-01       Impact factor: 21.198

Review 9.  Cholesterol in the retina: the best is yet to come.

Authors:  Irina A Pikuleva; Christine A Curcio
Journal:  Prog Retin Eye Res       Date:  2014-04-04       Impact factor: 21.198

10.  Spatial distribution of the pathways of cholesterol homeostasis in human retina.

Authors:  Wenchao Zheng; Rachel E Reem; Saida Omarova; Suber Huang; Pier Luigi DiPatre; Casey D Charvet; Christine A Curcio; Irina A Pikuleva
Journal:  PLoS One       Date:  2012-05-22       Impact factor: 3.240
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