Literature DB >> 7065524

Bronchial secretion concentrations of tobramycin.

M R Alexander, J Schoell, G Hicklin, J E Kasik, D Coleman.   

Abstract

The mean concentrations of tobramycin in bronchial secretions from patients with pneumonia were almost two times greater than secretions from patients free of lung infection. Mean tobramycin bronchial secretion to serum concentration ratios also were higher when obtained from infected lungs (0.66 versus 0.17) These data suggest that lung infection enhances the concentrations of tobramycin in bronchial secretions.

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Year:  1982        PMID: 7065524     DOI: 10.1164/arrd.1982.125.2.208

Source DB:  PubMed          Journal:  Am Rev Respir Dis        ISSN: 0003-0805


  4 in total

Review 1.  Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.

Authors:  J Prandota
Journal:  Drugs       Date:  1988-05       Impact factor: 9.546

2.  Penetration of cefotaxime into respiratory secretions.

Authors:  R B Fick; M R Alexander; R A Prince; J E Kasik
Journal:  Antimicrob Agents Chemother       Date:  1987-05       Impact factor: 5.191

Review 3.  Assessment of drug disposition in the lung.

Authors:  A S Rebuck; A C Braude
Journal:  Drugs       Date:  1984-12       Impact factor: 9.546

4.  Systemic absorption of endotracheally administered aminoglycosides in seriously ill patients with pneumonia.

Authors:  S S Crosby; W A Edwards; C Brennan; E P Dellinger; L A Bauer
Journal:  Antimicrob Agents Chemother       Date:  1987-06       Impact factor: 5.191

  4 in total

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