Literature DB >> 706536

Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.

B Heymer, H Finger, C H Wirsing.   

Abstract

The adjuvant activity of the synthetic muramyl-dipeptide (MDP) N-acetyl-muramyl-L-alanyl-D-isoglutamine upon immunization of mice with BSA or SRBC was studied. MDP was found to significantly increase BSA-antibody formation and to favour the induction of anaphylactic reactions to BSA. In contrast, under the conditions employed, MDP only weakly stimulated the immune response to SRBC.

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Year:  1978        PMID: 706536

Source DB:  PubMed          Journal:  Z Immunitatsforsch Immunobiol        ISSN: 0340-904X


  4 in total

1.  Failure of synthetic muramyl dipeptide to increase antibacterial resistance.

Authors:  H Finger; C H Wirsing von König
Journal:  Infect Immun       Date:  1980-02       Impact factor: 3.441

Review 2.  Muramyl peptides. Chemical structure, biological activity and mechanism of action.

Authors:  A Adam; J F Petit; P Lefrancier; E Lederer
Journal:  Mol Cell Biochem       Date:  1981-12-04       Impact factor: 3.396

3.  The comparative selectivity of adjuvants for humoral and cell-mediated immunity. I. Effect on the antibody response to bovine serum albumin and sheep red blood cells of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.

Authors:  R Bomford
Journal:  Clin Exp Immunol       Date:  1980-02       Impact factor: 4.330

Review 4.  Regulation of Immune Homeostasis via Muramyl Peptides-Low Molecular Weight Bioregulators of Bacterial Origin.

Authors:  Svetlana V Guryanova
Journal:  Microorganisms       Date:  2022-07-28
  4 in total

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