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Literature DB >> 7061574

Tumor promoter-stimulated synthesis of Mason-:Pfizer monkey virus.

Abstract

The tumor promoter 12-0-tetradecanoyl-phorbol-14-acetate (TPA) increases by severalfold the synthesis of Mason-Pfizer monkey virus (MPMV), a type D retrovirus, when the virus is growing in human embryo kidney (HEK) cells. The effect is transient and paralleled by a striking morphological alteration of the cells. The optimal TPA concentration for stimulation is 5 ng. ml-1. Contrary to infected HEK cells, TPA induces at similar concentrations neither stimulation of MPMV synthesis nor altered morphology in persistently MPMV-infected cells of the continuous human tumor cell line A 204.

Entities: Chemical Disease Species

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Year: 1982 PMID： 7061574 DOI： 10.1007/bf00411347

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

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References

15 in total

1. Tumour promoter TPA enhances transformation of human leukocytes by Epstein-Barr virus.

Authors: N Yamamoto; H zur Hausen
Journal: Nature Date: 1979-07-19 Impact factor: 49.962

2. Persisting oncogenic herpesvirus induced by the tumour promotor TPA.

Authors: H zur Hausen; F J O'Neill; U K Freese; E Hecker
Journal: Nature Date: 1978-03-23 Impact factor: 49.962

3. Tumor initiators and promoters in the induction of Epstein-Barr virus.

Authors: H zur Hausen; G W Bornkamm; R Schmidt; E Hecker
Journal: Proc Natl Acad Sci U S A Date: 1979-02 Impact factor: 11.205

4. A new virus in a spontaneous mammary tumor of a rhesus monkey.

Authors: H C Chopra; M M Mason
Journal: Cancer Res Date: 1970-08 Impact factor: 12.701

Review 5. Reversible inhibition of cell differentiation by phorbol esters as a possible mechanism of the promotion step in chemical carcinogenesis.

Authors: H Yamasaki
Journal: IARC Sci Publ Date: 1980

Tumor promoter-stimulated synthesis of Mason-:Pfizer monkey virus.

1. Tumour promoter TPA enhances transformation of human leukocytes by Epstein-Barr virus.

2. Persisting oncogenic herpesvirus induced by the tumour promotor TPA.

3. Tumor initiators and promoters in the induction of Epstein-Barr virus.

4. A new virus in a spontaneous mammary tumor of a rhesus monkey.

Review 5. Reversible inhibition of cell differentiation by phorbol esters as a possible mechanism of the promotion step in chemical carcinogenesis.

Review 6. Tumor promotion and preneoplastic progression.

7. Occurrence of Mason-Pfizer monkey virus in healthy rhesus monkeys.

8. Characterization of infection and replication of Mason-Pfizer monkey virus in human cell cultures.

Review 9. Type D primate retroviruses: a review.

10. Expression of Mason-Pfizer and simian type C viruses in the presence of 5-iododeoxyuridine and dexamethasone.