Literature DB >> 7061570

Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters.

U Green, J Althoff.   

Abstract

Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract where a positive dose-response relationship was established for neoplastic growth.

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Year:  1982        PMID： 7061570     DOI： 10.1007/bf00411342

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  15 in total

1.  INDUCTION OF OLFACTORY NEUROEPITHELIAL TUMORS IN SYRIAN HAMSTERS BY DIETHYLNITROSAMINE.

Authors:  K M HERROLD
Journal:  Cancer       Date:  1964-01       Impact factor: 6.860

2.  [Proliferation-promoting and-inhibitory effects of sex hormones in the treatment of golden hamsters with carcinogens].

Authors:  W DONTENWILL; U MOHR
Journal:  Z Krebsforsch       Date:  1961

3.  Metabolism of nitrosamines in vivo. II. On the methylation of nucleic acids by aliphatic di-n-alkyl-nitrosamines in vivo, caused by beta-oxydation: the increased formation of 7-methyl-guanine after application of beta-hydroxypropyl-propyl-nitrosamine compared to that after application of di-n-propyl-nitrosamine.

Authors:  F W Krüger
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973

4.  Effect of beta-oxidized nitrosamines on Syrian golden hamsters. I. 2-Hydroxy-propyl-n-propylnitrosamine.

Authors:  P Pour; F W Krüger; J Althoff; A Cardesa; U Mohr
Journal:  J Natl Cancer Inst       Date:  1974-04       Impact factor: 13.506

5.  Carcinogenic response of the respiratory tract of Syrain golden hamsters to different doses of diethylnitrosamine.

Authors:  R Montesano; U Saffiotti
Journal:  Cancer Res       Date:  1968-11       Impact factor: 12.701

6.  Experimental studies on the organotropic effect of nitrosamines in the respiratory tract.

Authors:  W Dontenwill
Journal:  Food Cosmet Toxicol       Date:  1968-12

7.  Diaplacental effect of the carcinogen diethylnitrosamine in the golden hamster.

Authors:  U Mohr; J Althoff; A Authaler
Journal:  Cancer Res       Date:  1966-11       Impact factor: 12.701

8.  [Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].

Authors:  F W Krüger
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1971

9.  Induction of tumors in the Syrian hamster with diethylnitrosamine (N-nitrosodiethylamine).

Authors:  K M HERROLD; L J DUNHAM
Journal:  Cancer Res       Date:  1963-06       Impact factor: 12.701

10.  Vinylethylnitrosamine: a potent respiratory carcinogen in Syrian hamsters.

Authors:  J Althoff; C Grandjean; L Russell; P Pour
Journal:  J Natl Cancer Inst       Date:  1977-02       Impact factor: 13.506
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  1 in total

1.  Characterization of hepatic and pulmonary cytochromes P-450 in 3-methylcholanthrene-treated hamsters.

Authors:  M Watanabe; H Fujii; I Sagami; M Tanno
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153
  1 in total

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