Literature DB >> 7061385

Penicillin is an active-site inhibitor for four genera of bacteria.

R R Yocum, H Amanuma, T A O'Brien, D J Waxman, J L Strominger.   

Abstract

The hypothesis that penicillin acts as an active-site inhibitor cell wall biosynthesis was tested by a method of partial proteolytic mapping of penicillin-binding sites versus substrate-binding sites in cell wall D-alanine carboxypeptidases. This enzyme was obtained from four genera of bacteria, purified, and tested.

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Year:  1982        PMID： 7061385      PMCID： PMC216510          DOI： 10.1128/jb.149.3.1150-1153.1982

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  11 in total

Review 1.  Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.

Authors:  P M Blumberg; J L Strominger
Journal:  Bacteriol Rev       Date:  1974-09

2.  The penicillin receptor in Streptomyces.

Authors:  J M Ghuysen; M Leyh-Bouille; J M Frère; J Dusart; A Marquet
Journal:  Ann N Y Acad Sci       Date:  1974-05-10       Impact factor: 5.691

3.  A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.

Authors:  W M Bonner; R A Laskey
Journal:  Eur J Biochem       Date:  1974-07-01

4.  Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis.

Authors:  E M Wise; J T Park
Journal:  Proc Natl Acad Sci U S A       Date:  1965-07       Impact factor: 11.205

5.  Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.

Authors:  D J Tipper; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1965-10       Impact factor: 11.205

6.  The mechanism of action of penicillin. Penicillin acylates the active site of Bacillus stearothermophilus D-alanine carboxypeptidase.

Authors:  R R Yocum; J R Rasmussen; J L Strominger
Journal:  J Biol Chem       Date:  1980-05-10       Impact factor: 5.157

7.  A membrane enzyme from Staphylococcus aureus which catalyzes transpeptidase, carboxypeptidase, and penicillinase activities.

Authors:  J W Kozarich; J L Strominger
Journal:  J Biol Chem       Date:  1978-02-25       Impact factor: 5.157

8.  On the process of cellular division in Escherichia coli: isolation and characterization of penicillin-binding proteins 1a, 1b, and 3.

Authors:  T Tamura; H Suzuki; Y Nishimura; J Mizoguchi; Y Hirota
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

9.  Purification and properties of penicillin-binding proteins 5 and 6 from Escherichia coli membranes.

Authors:  H Amanuma; J L Strominger
Journal:  J Biol Chem       Date:  1980-12-10       Impact factor: 5.157

10.  Utilization of a depsipeptide substrate for trapping acyl-enzyme intermediates of penicillin-sensitive D-alanine carboxypeptidases.

Authors:  J R Rasmussen; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205
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  7 in total

Review 1.  Catalytic properties of class A beta-lactamases: efficiency and diversity.

Authors:  A Matagne; J Lamotte-Brasseur; J M Frère
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

2.  Active-site-serine D-alanyl-D-alanine-cleaving-peptidase-catalysed acyl-transfer reactions. Procedures for studying the penicillin-binding proteins of bacterial plasma membranes.

Authors:  J M Ghuysen; J M Frère; M Leyh-Bouille; M Nguyen-Distèche; J Coyette
Journal:  Biochem J       Date:  1986-04-01       Impact factor: 3.857

3.  Stability and synthesis of the penicillin-binding proteins during sporulation.

Authors:  C E Buchanan; M O Sowell
Journal:  J Bacteriol       Date:  1983-11       Impact factor: 3.490

4.  Ongoing purifying selection on intergenic spacers in group A streptococcus.

Authors:  Haiwei Luo; Jijun Tang; Robert Friedman; Austin L Hughes
Journal:  Infect Genet Evol       Date:  2010-11-27       Impact factor: 3.342

5.  Sequences of the active-site peptides of three of the high-Mr penicillin-binding proteins of Escherichia coli K-12.

Authors:  W Keck; B Glauner; U Schwarz; J K Broome-Smith; B G Spratt
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

6.  Molecular basis of the non-beta-lactamase-mediated resistance to beta-lactam antibiotics in strains of Haemophilus influenzae isolated in Canada.

Authors:  N Clairoux; M Picard; A Brochu; N Rousseau; P Gourde; D Beauchamp; T R Parr; M G Bergeron; F Malouin
Journal:  Antimicrob Agents Chemother       Date:  1992-07       Impact factor: 5.191

7.  Production of thiol-penicillin-binding protein 3 of Escherichia coli using a two primer method of site-directed mutagenesis.

Authors:  J K Broome-Smith; P J Hedge; B G Spratt
Journal:  EMBO J       Date:  1985-01       Impact factor: 11.598
  7 in total

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