| Literature DB >> 7060713 |
N Blavet, F V DeFeudis, F Clostre.
Abstract
In a model of conditioned feeding behavior, oral administration of cyproheptadine (1-100 mg/kg), 30 min before presentation of food, produced a dose-dependent reduction of food intake in the rat (ED50 congruent to 17 mg/kg during the 1st h of testing). This anorexic effect persisted for at least 24 h. These results provide further evidence that under certain conditions cyproheptadine, which is used as an orectic agent in man, can produce anorexia.Entities:
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Year: 1982 PMID： 7060713 DOI： 10.1007/bf01945104
Source DB: PubMed Journal: Experientia ISSN： 0014-4754