Literature DB >> 70592

Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?

C W van Veelen, G E Staal, H Verbiest, A M Vlug.   

Abstract

In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine. This study demonstrates the appearance of the MII-type isoenzyme in various gliomas. This MII type is also found in meningiomas but not in normal brain tissue. The method of enzyme examination described may be valuable as a diagnostic aid in the surgery of gliomas.

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Year:  1977        PMID： 70592     DOI： 10.1016/s0140-6736(77)90308-7

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  8 in total

1.  Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.

Authors:  Charles Kung; Jeff Hixon; Sung Choe; Kevin Marks; Stefan Gross; Erin Murphy; Byron DeLaBarre; Giovanni Cianchetta; Shalini Sethumadhavan; Xiling Wang; Shunqi Yan; Yi Gao; Cheng Fang; Wentao Wei; Fan Jiang; Shaohui Wang; Kevin Qian; Jeff Saunders; Ed Driggers; Hin Koon Woo; Kaiko Kunii; Stuart Murray; Hua Yang; Katharine Yen; Wei Liu; Lewis C Cantley; Matthew G Vander Heiden; Shinsan M Su; Shengfang Jin; Francesco G Salituro; Lenny Dang
Journal:  Chem Biol       Date:  2012-09-21

2.  Fourth European lecture. Words, images, knowledge, and reality. Some reflections from the neurosurgical perspective.

Authors:  H Verbiest
Journal:  Acta Neurochir (Wien)       Date:  1983       Impact factor: 2.216

3.  Anchorless 23-230 PrPC interactomics for elucidation of PrPC protective role.

Authors:  Saima Zafar; Abdul R Asif; Sanja Ramljak; Waqas Tahir; Matthias Schmitz; Inga Zerr
Journal:  Mol Neurobiol       Date:  2014-01-05       Impact factor: 5.590

4.  Pyruvate kinase inhibition in the diagnosis of gliomas with an intermediate degree of malignancy.

Authors:  H W Mostert; N J de Both; E H Rhijnsburger; W M Mackay; J H van den Berge; S Z Stefanko
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

5.  Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Authors:  Sophia Y Lunt; Vinayak Muralidhar; Aaron M Hosios; William J Israelsen; Dan Y Gui; Lauren Newhouse; Martin Ogrodzinski; Vivian Hecht; Kali Xu; Paula N Marín Acevedo; Daniel P Hollern; Gary Bellinger; Talya L Dayton; Stefan Christen; Ilaria Elia; Anh T Dinh; Gregory Stephanopoulos; Scott R Manalis; Michael B Yaffe; Eran R Andrechek; Sarah-Maria Fendt; Matthew G Vander Heiden
Journal:  Mol Cell       Date:  2014-12-04       Impact factor: 17.970

6.  ERK2-Pyruvate Kinase Axis Permits Phorbol 12-Myristate 13-Acetate-induced Megakaryocyte Differentiation in K562 Cells.

Authors:  Noor Chaman; Mohammad Askandar Iqbal; Farid Ahmad Siddiqui; Prakasam Gopinath; Rameshwar N K Bamezai
Journal:  J Biol Chem       Date:  2015-08-12       Impact factor: 5.157

7.  Discrimination between neuronal and glial cell tumours by pyruvate kinase electrophoresis.

Authors:  C W van Veelen; G Rijksen; G E Staal
Journal:  Acta Neurochir (Wien)       Date:  1988       Impact factor: 2.216

Review 8.  A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme.

Authors:  Harkomal Verma; Ravi P Cholia; Sharanjot Kaur; Monisha Dhiman; Anil K Mantha
Journal:  Metab Brain Dis       Date:  2021-03-02       Impact factor: 3.584
  8 in total

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