Literature DB >> 7059095

Clonidine and lidamidine to inhibit watery diarrhea in a patient with lung cancer.

K E McArthur, D S Anderson, T E Durbin, M J Orloff, K Dharmsathaphorn.   

Abstract

A patient with watery diarrhea syndrome secondary to bronchogenic carcinoma responded to treatment with clonidine and lidamidine. Stool weight decreased to 43% and 53% of control on two separate trials of clonidine. Stool weight decreased to 35% of control during a trial of lidamidine. Both clonidine and lidamidine increased sodium and chloride absorption in vitro in human intestine. Clonidine, lidamidine, or drugs that are structurally similar may become therapeutic choices for secretory diarrhea.

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Year:  1982        PMID： 7059095     DOI： 10.7326/0003-4819-96-3-323

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN： 0003-4819            Impact factor:   25.391


  16 in total

Review 1.  Palliative medicine.

Authors:  R J George; A L Jennings
Journal:  Postgrad Med J       Date:  1993-06       Impact factor: 2.401

2.  Effect of lidamidine on transepithelial potential difference evoked by prostaglandin E2 in human jejunum.

Authors:  H Masukawa; M Kaneko; T Takahashi; M Ishikawa; Y Suzuki
Journal:  Gastroenterol Jpn       Date:  1987-10

Review 3.  Pharmacoeconomics of the therapy of diarrhoeal disease.

Authors:  K A Nathavitharana; I W Booth
Journal:  Pharmacoeconomics       Date:  1992-10       Impact factor: 4.981

4.  Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.

Authors:  P Baumer; E Danquechin Dorval; J Bertrand; J M Vetel; J C Schwartz; J M Lecomte
Journal:  Gut       Date:  1992-06       Impact factor: 23.059

5.  What about clonidine for diarrhoea? A systematic review and meta-analysis of its effect in humans.

Authors:  Konstantinos C Fragkos; Natalia Zárate-Lopez; Christos C Frangos
Journal:  Therap Adv Gastroenterol       Date:  2016-01-25       Impact factor: 4.409

6.  Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa.

Authors:  P Valet; J M Senard; J C Devedjian; V Planat; R Salomon; T Voisin; G Drean; A Couvineau; D Daviaud; C Denis
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

7.  Effect of alpha-methylnorepinephrine, an alpha 2-adrenergic agonist, on jejunal absorption in neurally intact conscious dog.

Authors:  S M Herkes; C D Smith; L P Prabhakar; S F Phillips; M G Sarr
Journal:  Dig Dis Sci       Date:  1993-09       Impact factor: 3.199

Review 8.  Antidiarrheal therapy. Prospects for new agents.

Authors:  R N Fedorak; M Field
Journal:  Dig Dis Sci       Date:  1987-02       Impact factor: 3.199

9.  Dexmedetomidine stops benzodiazepine-refractory nerve agent-induced status epilepticus.

Authors:  Hilary S McCarren; Julia A Arbutus; Cherish Ardinger; Emily N Dunn; Cecelia E Jackson; John H McDonough
Journal:  Epilepsy Res       Date:  2018-01-31       Impact factor: 3.045

10.  Regulation of rat ileal water absorption by central alpha 2 adrenergic receptors.

Authors:  R Fogel; T H Kong; W H Dong; M Pfeiffer; G Michelson
Journal:  Dig Dis Sci       Date:  1990-06       Impact factor: 3.199
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