| Literature DB >> 705860 |
G Rock, V E Secours, C A Franklin, I Chu, D C Villeneuve.
Abstract
The accumulation of the plasticizer di-2-ethylhexylphthalate (DEHP) in blood and blood components has been of considerable concern for some time. We have followed the accumulation of DEHP and one of its major metabolities, mono-2-ethylhexylphthalate (MEHP) during storage of whole blood, platelet-rich plasma, platelet concentrates, and platelet-poor plasma for periods ranging from 72 hours to four weeks. Both phthalates showed a progressive increase in concentration with time. While the levels of DEHP were much greater than those of MEHP, there was nonetheless a significant and continual increase in MEHP in all preparations. The highest concentrations of both DEHP and MEHP were found in the platelet-poor plasma, indicating that platelets do not have a major role in the accumulation of the phthalates in blood. The accumulation of MEHP was shown to be a direct result of the metabolism of DEHP by plasma protein(s) rather than leaching from the blood bag.Entities:
Mesh：
Substances：
Year: 1978 PMID： 705860 DOI： 10.1046/j.1537-2995.1978.18579036383.x
Source DB: PubMed Journal: Transfusion ISSN： 0041-1132 Impact factor: 3.157