Literature DB >> 7058211

Parameters of low-dose ethanol intravenous self-administration in the rat.

J D Sinden, J Le Magnen.   

Abstract

Male Wistar rats were able to press on an operant lever 24 hr/day for intravenous infusions of saline or ethanol at doses of 0.5, 1.0 or 5.0 mg/kg/infusion. Only the 1.0 mg/kg/infusion group showed a significant increase in responding on the lever as a function of days, whereas the 5.0 mg/kg/infusion group showed a significant decrease in responding as a function of days. The results suggest that the reinforcing value of intravenous ethanol changes from rewarding to neutral or aversive in valence at dose-level below that expected to produce signs of intoxication.

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Year:  1982        PMID： 7058211     DOI： 10.1016/0091-3057(82)90033-8

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  11 in total

1.  Intravenous heroin and ethanol self-administration by alcohol-preferring AA and alcohol-avoiding ANA rats.

Authors:  P Hyytiä; G Schulteis; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1996-06       Impact factor: 4.530

2.  Nicotine and ethanol co-use in Long-Evans rats: Stimulatory effects of perinatal exposure to a fat-rich diet.

Authors:  Olga Karatayev; Olga Lukatskaya; Sang-Ho Moon; Wei-Ran Guo; Dan Chen; Diane Algava; Susan Abedi; Sarah F Leibowitz
Journal:  Alcohol       Date:  2015-04-11       Impact factor: 2.405

Review 3.  Intravenous self-administration of alcohol in rats-problems with translation to humans.

Authors:  Anh D Lê; Harold Kalant
Journal:  Addict Biol       Date:  2016-08-02       Impact factor: 4.280

4.  Prediction of abuse liability of drugs using IV self-administration by rats.

Authors:  R J Collins; J R Weeks; M M Cooper; P I Good; R R Russell
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

5.  Prediction and Prevention of Prescription Drug Abuse: Role of Preclinical Assessment of Substance Abuse Liability.

Authors:  Julie A Marusich; Timothy W Lefever; Scott P Novak; Bruce E Blough; Jenny L Wiley
Journal:  Methods Rep RTI Press       Date:  2013-07

6.  Contingent and non-contingent effects of low-dose ethanol on GABA neuron activity in the ventral tegmental area.

Authors:  Scott C Steffensen; Christine H Walton; David M Hansen; Jordan T Yorgason; Roger A Gallegos; Jose R Criado
Journal:  Pharmacol Biochem Behav       Date:  2008-10-29       Impact factor: 3.533

7.  Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.

Authors:  Justin T Gass; M Foster Olive
Journal:  Psychopharmacology (Berl)       Date:  2009-02-19       Impact factor: 4.530

8.  Induction and maintenance of ethanol self-administration without food deprivation in the rat.

Authors:  K A Grant; H H Samson
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

9.  Contingent and non-contingent recreational-like exposure to ethanol alters BDNF expression and signaling in the cortico-accumbal network differently.

Authors:  Alessandro Orrù; Lucia Caffino; Federico Moro; Chiara Cassina; Giuseppe Giannotti; Angelo Di Clemente; Fabio Fumagalli; Luigi Cervo
Journal:  Psychopharmacology (Berl)       Date:  2016-07-01       Impact factor: 4.530

10.  Intravenous alcohol self-administration in the P rat.

Authors:  Kyle A Windisch; Ann E K Kosobud; Cristine L Czachowski
Journal:  Alcohol       Date:  2014-04-21       Impact factor: 2.405
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