Literature DB >> 7056618

Tissue distribution of 3H-hematoporphyrin derivative in athymic "nude" mice heterotransplanted with human retinoblastoma.

C J Gomer, N Rucker, C Mark, W F Benedict, A L Murphree.   

Abstract

Quantitative uptake levels of tritium-labeled hematoporphyrin derivative (3H-HpD) have been obtained for normal and malignant tissue of athymic "nude" mice heterotransplanted intraocularly with human retinoblastoma. It was determined that eyes with tumor accumulated higher levels of 3H-HpD than those in control eyes. In addition, an improved therapeutic retention ratio of the drug (eyes with tumor compared with control eyes) was obtained at extended time intervals after administration.

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Year:  1982        PMID： 7056618

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  6 in total

1.  Observations in studies of quantitative kinetics of tritium labelled hematoporphyrin derivatives (HpDI and HpDII) in the normal and neoplastic rat brain model.

Authors:  F M Little; C J Gomer; S Hyman; M L Apuzzo
Journal:  J Neurooncol       Date:  1984       Impact factor: 4.130

2.  Selective incorporation of 111In-labeled PHOTOFRIN by glioma tissue in vivo.

Authors:  H T Whelan; L H Kras; K Ozker; D Bajic; M H Schmidt; Y Liu; L A Trembath; F Uzum; G A Meyer; A D Segura
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

3.  Penetration of hematoporphyrin derivative into rat brain and intracerebral 9L glioma tissue.

Authors:  D P Boisvert; J D McKean; J Tulip; J Cummins; M K Cheng
Journal:  J Neurooncol       Date:  1985       Impact factor: 4.130

4.  Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin.

Authors:  T Christensen; T Sandquist; K Feren; H Waksvik; J Moan
Journal:  Br J Cancer       Date:  1983-07       Impact factor: 7.640

5.  Cerebral photosensitisation by haematoporphyrin derivative. Evidence for an endothelial site of action.

Authors:  M C Berenbaum; G W Hall; A D Hoyes
Journal:  Br J Cancer       Date:  1986-01       Impact factor: 7.640

6.  Ineffective photodynamic therapy (PDT) in a poorly vascularized xenograft model.

Authors:  L White; C J Gomer; D R Doiron; B C Szirth
Journal:  Br J Cancer       Date:  1988-05       Impact factor: 7.640
  6 in total

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