Literature DB >> 7056366

Precipitate formation of some sulfonated tetrazolthiomethyl cephalosporins with basic chemicals.

J V Uri, P Actor.   

Abstract

Cephalosporins containing a thiomethyltetrazole-sulfomethyl or sulfoaminoethyl substituent at the three-position react in aqueous solution with protamine or quinine to form a precipitate. This phenomenon may provide some insight into their pharmacokinetics and modes of action especially as it relates to the high and prolonged serum levels and high degree of serum protein-binding.

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Year:  1982        PMID： 7056366     DOI： 10.1007/bf01944543

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

Review 1.  Suramin: with special reference to onchocerciasis.

Authors:  F Hawking
Journal:  Adv Pharmacol Chemother       Date:  1978

2.  SK&F 75073, new parenteral broad-spectrum cephalosporin with high and prolonged serum levels.

Authors:  P Actor; J V Uri; I Zajac; J R Guarini; L Phillips; D H Pitkin; D A Berges; G L Dunn; J R Hoover; J A Weisbach
Journal:  Antimicrob Agents Chemother       Date:  1978-05       Impact factor: 5.191

3.  In vitro and in vivo laboratory studies on three hydroxyiminophenylacetyl cephalosporins with particular reference to SK&F 80303, an unusually long-acting cephalosporin.

Authors:  J V Uri; P Actor; I Zajac; D H Pitkin; L Phillips; J R Guarini; H F Bartus; T J Polansky; G L Dunn; J R Hoover; J A Weisbach
Journal:  J Antibiot (Tokyo)       Date:  1979-11       Impact factor: 2.649

4.  Sulfazecin and isosulfazecin, novel beta-lactam antibiotics of bacterial origin.

Authors:  A Imada; K Kitano; K Kintaka; M Muroi; M Asai
Journal:  Nature       Date:  1981-02-12       Impact factor: 49.962
  4 in total

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