| Literature DB >> 7056024 |
M Eichelbaum, L Bertilsson, J Säwe, C Zekorn.
Abstract
Thirty-eight healthy subjects were given single oral doses of debrisoquine and sparteine in a crossover study. The close correlation between urinary metabolic ratios of the two drugs (rs = 0.91; P less than 0.001) demonstrates that the polymorphic N-oxidation of sparteine and 4-hydroxylation of debrisoquine are related pharmacogenetic entities; the metabolism of the two drugs is regulated by identical or closely related genetic factors.Entities:
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Year: 1982 PMID： 7056024 DOI： 10.1038/clpt.1982.29
Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875