| Literature DB >> 7056020 |
S M Pond, T G Tong, N L Benowitz, P Jacob, J Rigod.
Abstract
Four methadone-maintained subjects were given diazepam (0.3 mg/kg) for 9 days. During the dual drug period, the effects and kinetics of methadone and of its major pyrrolidine metabolite were not altered. These findings indicate that, unlike its effects in rodents, diazepam does not inhibit the metabolism of methadone in man.Entities:
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Year: 1982 PMID： 7056020 DOI： 10.1038/clpt.1982.22
Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875