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Literature DB >> 7055567

Divalent cations and chlorpromazine can induce non-bilayer structures in phosphatidic acid-containing model membranes.

A J Verkleij, R De Maagd, J Leunissen-Bijvelt, B De Kruijff.

Abstract

(1) The structural organization of aqueous dispersions of 1,2-dioleoylphosphatidic acid has been investigated by freeze-fracture electron microscopy in relation to variations in pH, divalent cations and the local anaesthetic chlorpromazine. (2) In the pH range 4--8 in the presence of 100 mM Na+, dioleoylphosphatidic acid is organized in bilayers. (3) At pH 6 and not at pH 4 and 8.5 addition of Ca2+, Mg2+, Mn2+ and chlorpromazine results in the formation of the hexagonal HII phase. (4) Ca2+ and chlorpromazine addition to mixed phosphatidylcholine-dioleoylphosphatidic acid bilayers at pH 6 results in the formation of lipidic particles.

Entities: Chemical

Mesh：

Substances：

Year: 1982 PMID： 7055567 DOI： 10.1016/0005-2736(82)90014-1

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

30 in total

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2. DIACYLGLYCEROL ACYLTRANSFERASE and DIACYLGLYCEROL KINASE Modulate Triacylglycerol and Phosphatidic Acid Production in the Plant Response to Freezing Stress.

Authors: Wei-Juan Tan; Yi-Cong Yang; Ying Zhou; Li-Ping Huang; Le Xu; Qin-Fang Chen; Lu-Jun Yu; Shi Xiao
Journal: Plant Physiol Date: 2018-05-31 Impact factor: 8.340

10. Phosphatidic acid induces leaf cell death in Arabidopsis by activating the Rho-related small G protein GTPase-mediated pathway of reactive oxygen species generation.

Authors: Jumok Park; Ying Gu; Yuree Lee; Zhenbiao Yang; Youngsook Lee
Journal: Plant Physiol Date: 2004-01 Impact factor: 8.340

Divalent cations and chlorpromazine can induce non-bilayer structures in phosphatidic acid-containing model membranes.

1. The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast.

2. DIACYLGLYCEROL ACYLTRANSFERASE and DIACYLGLYCEROL KINASE Modulate Triacylglycerol and Phosphatidic Acid Production in the Plant Response to Freezing Stress.

3. Calcium-induced fusion of didodecylphosphate vesicles: the lamellar to hexagonal II (HII) phase transition.

Review 4. Role of inositol trisphosphate as a second messenger in signal transduction processes: an essay.

5. Evidence for the extended phospholipid conformation in membrane fusion and hemifusion.

6. Disruption of the Arabidopsis Defense Regulator Genes SAG101, EDS1, and PAD4 Confers Enhanced Freezing Tolerance.

Review 7. Counterion-mediated pattern formation in membranes containing anionic lipids.

8. Transbilayer diffusion of divalent cations into liposomes mediated by lipidic particles of phosphatidate.

9. Proteolysis of ankyrin and of band 3 protein in chemically induced cell fusion. Ca2+ is not mandatory for fusion.

10. Phosphatidic acid induces leaf cell death in Arabidopsis by activating the Rho-related small G protein GTPase-mediated pathway of reactive oxygen species generation.