Literature DB >> 7054221

Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia.

M C de Vernejoul, R Girot, J Gueris, L Cancela, S Bang, J Bielakoff, C Mautalen, D Goldberg, L Miravet.   

Abstract

Calcium and phosphate metabolism were studied in 22 patients with homozygous thalassemia. The overall results showed no significant difference for serum calcium, phosphorus, alkaline phosphatase, immunoreactive parathyroid hormone, or 25-hydroxyvitamin D between thalassemic and control children. However, during the winter, serum 25-hydroxycholecalciferol levels were very significantly decreased in thalassemic children. A study of the hands showed thin metacarpal cortices related to increased resorption. Histomorphometric study of four iliac bone biopsies showed normal osteoclastic resorption and decreased bone formation. Prussian blue staining and x-ray electron microprobe analysis showed iron deposits inside the bone. Whether this finding is critical in the pathogenesis of the bone disease in unknown.

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Year:  1982        PMID： 7054221     DOI： 10.1210/jcem-54-2-276

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  14 in total

1.  Does iron affect osteoblast function? Studies in vitro and in patients with chronic liver disease.

Authors:  T Diamond; R Pojer; D Stiel; A Alfrey; S Posen
Journal:  Calcif Tissue Int       Date:  1991-06       Impact factor: 4.333

2.  The unexpected presence of iron in bone biopsies of hemodialysis patients.

Authors:  Melani R Custodio; Rosilene M Elias; Wagner D Velasquez; Luciene M Dos Reis; Ivone B Oliveira; Rosa M A Moysés; Aluizio B Carvalho; Vanda Jorgetti
Journal:  Int Urol Nephrol       Date:  2018-08-22       Impact factor: 2.370

3.  Osteoporosis and beta-thalassemia major: role of the IGF-I/IGFBP-III axis.

Authors:  A Lasco; N Morabito; A Gaudio; A Crisafulli; A Meo; G Denuzzo; N Frisina
Journal:  J Endocrinol Invest       Date:  2002-04       Impact factor: 4.256

4.  Spontaneous multiple vertebral fractures revealed primary haemochromatosis.

Authors:  M Duquenne; V Rohmer; E Legrand; D Chappard; N Wion Barbot; M F Basle; M Audran; J C Bigorgne
Journal:  Osteoporos Int       Date:  1996       Impact factor: 4.507

5.  Effects of iron overload on bone remodeling in pigs.

Authors:  M C de Vernejoul; A Pointillart; C C Golenzer; C Morieux; J Bielakoff; D Modrowski; L Miravet
Journal:  Am J Pathol       Date:  1984-09       Impact factor: 4.307

6.  Endocrine and metabolic disorders in β-thalassemiamajor patients.

Authors:  Fatemeh Saffari; Abolfazl Mahyar; Shabnam Jalilolgadr
Journal:  Caspian J Intern Med       Date:  2012

7.  [Arthropathy in beta-thalassemia minor].

Authors:  J Richter; C Specker; U Mödder; M Schneider
Journal:  Med Klin (Munich)       Date:  2000-01-15

8.  Osteoporosis syndrome in thalassaemia major: an overview.

Authors:  Meropi Toumba; Nicos Skordis
Journal:  J Osteoporos       Date:  2010-05-26

9.  Iron distribution in thalassemic bone by energy-loss spectroscopy and electron spectroscopic imaging.

Authors:  C Bordat; A Constans; O Bouet; I Blanc; C L Trubert; R Girot; G Cournot
Journal:  Calcif Tissue Int       Date:  1993-07       Impact factor: 4.333

10.  Stainable bone iron in undecalcified, plastic-embedded sections. Occurrence in man related to the presence of "free" iron?

Authors:  H Laeng; T Egger; C Roethlisberger; H Cottier
Journal:  Am J Pathol       Date:  1988-05       Impact factor: 4.307
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