Literature DB >> 7053991

Parathyroid hormone stimulates mammalian renal 25-hydroxyvitamin D3-1 alpha-hydroxylase in vitro.

R Kremer, D Goltzman.   

Abstract

We have shown that parathyroid hormone (PTH) stimulates 25-hydroxyvitamin D2-1 alpha-hydroxylase activity in mitochondrial preparations of guinea pig kidney in vitro.1,25-[3H]dihydroxyvitamin D3 produced from 25-[3H]hydroxyvitamin D3 was identified by both normal phase and reversed-phase high pressure liquid chromatography. Enzyme stimulation by PTH was dose-dependent, peaked after 15 minutes of incubation with hormone and was maximal at concentrations of approximately 10(-10) M PTH-(1-84) and PTH-(1-34). This guinea pig renal model therefore permits direct examination of hormonal regulation of the mammalian enzyme in vitro.

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Year:  1982        PMID： 7053991     DOI： 10.1210/endo-110-1-294

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  6 in total

1.  Parathyroid hormone and transforming growth factor-beta1 coregulate chondrocyte differentiation in vitro.

Authors:  E Nasatzky; E Azran; D D Dean; B D Boyan; Z Schwartz
Journal:  Endocrine       Date:  2000-12       Impact factor: 3.633

Review 2.  High-Resolution Mass Spectrometry for the Measurement of PTH and PTH Fragments: Insights into PTH Physiology and Bioactivity.

Authors:  Candice Z Ulmer; Kittrawee Kritmetapak; Ravinder J Singh; Hubert W Vesper; Rajiv Kumar
Journal:  J Am Soc Nephrol       Date:  2022-04-08       Impact factor: 14.978

3.  Compensatory Changes in Calcium Metabolism Accompany the Loss of Vitamin D Receptor (VDR) From the Distal Intestine and Kidney of Mice.

Authors:  Perla C Reyes-Fernandez; James C Fleet
Journal:  J Bone Miner Res       Date:  2015-08-20       Impact factor: 6.741

Review 4.  Vitamin D metabolism and phosphate transport in developing kidney: effect of diet and mutation.

Authors:  H S Tenenhouse
Journal:  Pediatr Nephrol       Date:  1988-01       Impact factor: 3.714

5.  Long-term control of plasma calcitriol concentration in dogs and humans. Dominant role of plasma calcium concentration in experimental hyperparathyroidism.

Authors:  H N Hulter; B P Halloran; R D Toto; J C Peterson
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

Review 6.  Vitamin D Binding Protein and the Biological Activity of Vitamin D.

Authors:  Rene F Chun; Albert Shieh; Carter Gottlieb; Vahe Yacoubian; Jeffrey Wang; Martin Hewison; John S Adams
Journal:  Front Endocrinol (Lausanne)       Date:  2019-10-24       Impact factor: 6.055
  6 in total

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