Literature DB >> 7053569

Is the acetylcholine receptor a rabies virus receptor?

T L Lentz, T G Burrage, A L Smith, J Crick, G H Tignor.   

Abstract

Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with alpha-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. These findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. The binding of virus to acetylcholine receptors, which are present in high density at the neuromuscular junction, would provide a mechanism whereby the virus could be locally concentrated at sites in proximity to peripheral nerves facilitating subsequent uptake and transfer to the central nervous system.

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Year:  1982        PMID: 7053569     DOI: 10.1126/science.7053569

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  128 in total

1.  Fish rhabdovirus cell entry is mediated by fibronectin.

Authors:  M Bearzotti; B Delmas; A Lamoureux; A M Loustau; S Chilmonczyk; M Bremont
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

2.  Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein.

Authors:  Y Jacob; H Badrane; P E Ceccaldi; N Tordo
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

Review 3.  Virus receptors in the human central nervous system.

Authors:  B Schweighardt; W J Atwood
Journal:  J Neurovirol       Date:  2001-06       Impact factor: 2.643

4.  Molecular basis of neurovirulence of flury rabies virus vaccine strains: importance of the polymerase and the glycoprotein R333Q mutation.

Authors:  Lihong Tao; Jinying Ge; Xijun Wang; Hongyue Zhai; Tao Hua; Bolin Zhao; Dongni Kong; Chinglai Yang; Hualan Chen; Zhigao Bu
Journal:  J Virol       Date:  2010-06-10       Impact factor: 5.103

5.  Rabies.

Authors: 
Journal:  Curr Treat Options Neurol       Date:  2000-07       Impact factor: 3.598

Review 6.  Rabies pathogenesis.

Authors:  Alan C Jackson
Journal:  J Neurovirol       Date:  2002-08       Impact factor: 2.643

7.  Region at amino acids 164 to 303 of the rabies virus glycoprotein plays an important role in pathogenicity for adult mice.

Authors:  Mutsuyo Takayama-Ito; Naoto Ito; Kentaro Yamada; Nobuyuki Minamoto; Makoto Sugiyama
Journal:  J Neurovirol       Date:  2004-04       Impact factor: 2.643

8.  Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins. Is the nicotinic acetylcholine receptor an HIV receptor?

Authors:  P Neri; L Bracci; M Rustici; A Santucci
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

9.  Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor.

Authors:  Venice Du Pont; Christoph Wirblich; Jeong-Joong Yoon; Robert M Cox; Matthias J Schnell; Richard K Plemper
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

10.  The rabies virus glycoprotein determines the distribution of different rabies virus strains in the brain.

Authors:  Xiuzhen Yan; Puliyur S Mohankumar; Bernhard Dietzschold; Matthies J Schnell; Zhen F Fu
Journal:  J Neurovirol       Date:  2002-08       Impact factor: 2.643

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