The effect of prostaglandin inhibitors on wound contraction and the myofibroblast.

The production and smooth muscle-like activity of the myofibroblast do not appear to be diminished in a granulating wound treated with prostaglandin inhibitors. Prostaglandins are mediators of inflammation and smooth-muscle stimulants, but inhibition of the prostaglandins and their precursors failed to alter the course of wound contraction and, by inference, the activity of the myofibroblast in this experimental model.