| Literature DB >> 7052532 |
J W Olney, T de Gubareff, J F Collins.
Abstract
The glutamate (Glu) analog, DL-alpha-aminoadipate (DL-alpha AA), and the separate D and L isomers of alpha AA, were administered subcutaneously to infant mice and histopathological effects on the arcuate hypothalamic (AH) nucleus were studied. L-alpha AA induced striking gliotoxic and neurotoxic changes; D-alpha AA and DL-alpha AA respectively induced mild and extreme gliotoxic but not neurotoxic changes. The neurotoxicity of L-alpha AA is of interest in view of its known neuroexcitatory potential. The non-neurotoxicity of DL-alpha AA implies effective antagonism by D-alpha AA of the neurotoxicity of L-alpha AA, which is of interest in that D-alpha AA is recognized as an effective antagonist of amino acid excitants and is thought to block specifically at the excitatory receptor.Entities:
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Year: 1980 PMID： 7052532 DOI： 10.1016/0304-3940(80)90273-6
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046