Literature DB >> 7050255

The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes.

R L Friedman, J E Lochner, R H Bigley, B H Iglewski.   

Abstract

The effect of Legionella pneumophila toxin on selected functions of human polymorphonuclear leukocytes was investigated. Amounts of L. pneumophila toxin that had no effect on leukocyte viability or phagocytosis significantly decreased hexose monophosphate shunt activity and O2 consumption during phagocytosis and bacterial iodination and killing in a dose-dependent fashion. The mechanism of action of this toxin appears to be unique among bacterial products thus far studied.

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Year:  1982        PMID： 7050255     DOI： 10.1093/infdis/146.3.328

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  16 in total

Review 1.  The Jeremiah Metzger Lecture. Microbial defenses against killing by phagocytes.

Authors:  G L Mandell; M O Frank
Journal:  Trans Am Clin Climatol Assoc       Date:  1992

2.  Bordetella pertussis induces respiratory burst activity in human polymorphonuclear leukocytes.

Authors:  L L Steed; E T Akporiaye; R L Friedman
Journal:  Infect Immun       Date:  1992-05       Impact factor: 3.441

Review 3.  Virulence factors of the family Legionellaceae.

Authors:  J N Dowling; A K Saha; R H Glew
Journal:  Microbiol Rev       Date:  1992-03

4.  Legionella pneumophila inhibits protein synthesis in Chinese hamster ovary cells.

Authors:  K T McCusker; B A Braaten; M W Cho; D A Low
Journal:  Infect Immun       Date:  1991-01       Impact factor: 3.441

Review 5.  Pathogenesis of lower respiratory tract infections due to Chlamydia, Mycoplasma, Legionella and viruses.

Authors:  P Andersen
Journal:  Thorax       Date:  1998-04       Impact factor: 9.139

6.  Legionella brain stem encephalopathy and peripheral neuropathy without preceding pneumonia.

Authors:  P D Heath; L Booth; P N Leigh; A M Turner
Journal:  J Neurol Neurosurg Psychiatry       Date:  1986-02       Impact factor: 10.154

7.  A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection.

Authors:  N P Cianciotto; B I Eisenstein; C H Mody; G B Toews; N C Engleberg
Journal:  Infect Immun       Date:  1989-04       Impact factor: 3.441

8.  Treatment of alveolar macrophages with cytochalasin D inhibits uptake and subsequent growth of Legionella pneumophila.

Authors:  J A Elliott; W C Winn
Journal:  Infect Immun       Date:  1986-01       Impact factor: 3.441

Review 9.  Legionnaires disease: historical perspective.

Authors:  W C Winn
Journal:  Clin Microbiol Rev       Date:  1988-01       Impact factor: 26.132

10.  Fate of Legionella pneumophila Philadelphia-1 strain in resident, elicited, activated, and immune peritoneal macrophages of guinea pigs.

Authors:  S Yoshida; Y Mizuguchi; Y Nikaido; M Mitsuyama; K Nomoto
Journal:  Infect Immun       Date:  1987-10       Impact factor: 3.441
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