| Literature DB >> 704901 |
H R Knapp, O Oelz, B J Sweetman, J A Oates.
Abstract
Whole cell preparations of rat stomach corpus, jejunum, and colon were incubated and the released prostaglandin E2 (PGE2), PGF2alpha, PGD2, 15 keto-13,14 dihydro PGE2, and 15 keto-13, 14 dihydro PGF2alpha were measured by combined gas chromatography-mass spectrometry. All regions made PGD2 and possessed a high capacity for production 15 keto-13,14 dihydro derivatives of both PGE2 and PGF2alpha. Hypertonic sucrose solutions resulted in concentration-dependent increases in prostaglandin release, particularly of PGE2 and its metabolite. It is suggested that PG's may play a role in the local effects of luminal hyperosomolarity on digestive tract functions.Entities:
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Year: 1978 PMID： 704901 DOI： 10.1016/0090-6980(78)90141-7
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980