Literature DB >> 7048243

Renal handling of homologous and heterologous insulin in the isolated perfused rat kidney.

E Schlatter, H J Schurek, R Zick.   

Abstract

1. Renal handling of pig- and rat-insulin was studied in the isolated perfused rat kidney. 2. Metabolic clearance rates of both pig- and rat-insulin exceeded GFR. 3. Peritubular uptake of pig-insulin accounted for 13% of rat-insulin for 31% of the total metabolic clearance. 4. The nonfiltering kidney does not remove insulin from the peritubular circulation. 5. Metabolic clearance rates of pig- and rat-insulin are directly related to GFR. 6. The filtration process seems to be necessary for the uptake of insulin at the peritubular site.

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Year:  1982        PMID： 7048243     DOI： 10.1007/bf00584074

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  27 in total

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Authors:  F H SCHMIDT
Journal:  Klin Wochenschr       Date:  1961-12-01

2.  Distribution of membrane-bound cyclic AMP-dependent protein kinase in plasma membranes of cells of the kidney cortex.

Authors:  R Kinne; L J Shlatz; E Kinne-Saffran; I L Schwartz
Journal:  J Membr Biol       Date:  1975-11-07       Impact factor: 1.843

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Authors:  R Zwiebel; B Höhmann; P Frohnert; K Baumann
Journal:  Pflugers Arch       Date:  1969       Impact factor: 3.657

Review 4.  Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review.

Authors:  T Maack; V Johnson; S T Kau; J Figueiredo; D Sigulem
Journal:  Kidney Int       Date:  1979-09       Impact factor: 10.612

5.  Insulin uptake in the renal proximal tubule.

Authors:  J E Bourdeau; E R Chen; F A Carone
Journal:  Am J Physiol       Date:  1973-12

6.  The handling of insulin, proinsulin, and C-peptide by the isolated rat kidney.

Authors:  R Rabkin; B D Ross; M E Mako; A H Rubenstein
Journal:  Diabetes       Date:  1978       Impact factor: 9.461

7.  Renal handling of polypeptide hormones (insulin, C-peptide, h-PTH) as studied in the isolated perfused rat kidney.

Authors:  H J Schurek; E Schlatter; W Meier; R Zick; G Dorn; R Hehrmann; H Stolte
Journal:  Int J Biochem       Date:  1980

8.  Factors influencing the handling of insulin by the isolated rat kidney.

Authors:  R Rabkin; A E Kitabchi
Journal:  J Clin Invest       Date:  1978-07       Impact factor: 14.808

9.  Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH.

Authors:  A H Pekar; B H Frank
Journal:  Biochemistry       Date:  1972-10-24       Impact factor: 3.162

10.  Endocrinology and metabolism in uremia and dialysis: a clinical review.

Authors:  H A Feldman; I Singer
Journal:  Medicine (Baltimore)       Date:  1975-09       Impact factor: 1.889
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  1 in total

1.  Mathematical modeling and analysis of insulin clearance in vivo.

Authors:  Markus Koschorreck; Ernst Dieter Gilles
Journal:  BMC Syst Biol       Date:  2008-05-13
  1 in total

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