Literature DB >> 7048089

Peptidases from Plasmodium falciparum cultured in vitro.

F N Gyang, B Poole, W Trager.   

Abstract

An acid peptidase that degrades hemoglobin optimally at pH 3.5, a neutral aminopeptidase and an alkaline endopeptidase that acts on an alpha-N-blocked synthetic substrate have been demonstrated in Plasmodium falciparum in culture. The enzymes were shown to be distinct by anion exchange chromatography, gel filtration on Sephadex G-200 and isoelectric focusing. The activities of the acid peptidase and the aminopeptidase were inhibited by antimalarial compounds.

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Year:  1982        PMID： 7048089     DOI： 10.1016/0166-6851(82)90034-2

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  13 in total

Review 1.  Antimalarial agents: mechanisms of action.

Authors:  P H Schlesinger; D J Krogstad; B L Herwaldt
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

Review 2.  Malaria parasite plasmepsins: More than just plain old degradative pepsins.

Authors:  Armiyaw S Nasamu; Alexander J Polino; Eva S Istvan; Daniel E Goldberg
Journal:  J Biol Chem       Date:  2020-05-04       Impact factor: 5.157

3.  Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway.

Authors:  I Y Gluzman; S E Francis; A Oksman; C E Smith; K L Duffin; D E Goldberg
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

4.  Requirement of malarial protease in the invasion of human red cells by merozoites of Plasmodium falciparum.

Authors:  P Dejkriengkraikhul; P Wilairat
Journal:  Z Parasitenkd       Date:  1983

5.  In vitro translation and characterization of a unique histidine-rich protein mRNA in the avian malaria parasite Plasmodium lophurae.

Authors:  M Wallach; J D Boeke
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

6.  A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.

Authors:  P J Rosenthal; J H McKerrow; M Aikawa; H Nagasawa; J H Leech
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

7.  Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle.

Authors:  D E Goldberg; A F Slater; A Cerami; G B Henderson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

8.  Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors.

Authors:  Eithne Cunningham; Marcin Drag; Pawel Kafarski; Angus Bell
Journal:  Antimicrob Agents Chemother       Date:  2008-05-05       Impact factor: 5.191

9.  Identification of three stage-specific proteinases of Plasmodium falciparum.

Authors:  P J Rosenthal; K Kim; J H McKerrow; J H Leech
Journal:  J Exp Med       Date:  1987-09-01       Impact factor: 14.307

10.  Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine.

Authors:  A Yayon; Z I Cabantchik; H Ginsburg
Journal:  EMBO J       Date:  1984-11       Impact factor: 11.598
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