Literature DB >> 7047114

Plasma free insulin profiles after administration of insulin by jet and conventional syringe injection.

R Taylor, P D Home, K G Alberti.   

Abstract

Plasma free insulin profiles in insulin-dependent diabetic subjects were compared after jet and syringe injection of insulin. Jet injection of insulin resulted in a shift of the free insulin profile to the left. Thus higher plasma free insulin levels were found over the first 30 min after injection (P less than 0.05), while after 240 min plasma free insulin levels were lower than those seen following syringe injection (P less than 0.05). Significant differences in the response of blood glucose and 3-hydroxybutyrate levels reflected the differences in plasma free insulin levels. Jet administration results in more rapid absorption of insulin and could be useful in providing a more physiologic postprandial insulin profile than that seen after conventional injection.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7047114     DOI： 10.2337/diacare.4.3.377

Source DB:  PubMed          Journal:  Diabetes Care        ISSN： 0149-5992            Impact factor:   19.112


  10 in total

Review 1.  Recent developments in insulin delivery techniques. Current status and future potential.

Authors:  F P Kennedy
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

2.  Insulin bolus given by sprinkler needle: effect on absorption and glycaemic response to a meal.

Authors:  B Edsberg; D Herly; P Hildebrandt; C Kühl
Journal:  Br Med J (Clin Res Ed)       Date:  1987-05-30

Review 3.  Pharmacokinetics of insulin. Implications for continuous subcutaneous insulin infusion therapy.

Authors:  E W Kraegen; D J Chisholm
Journal:  Clin Pharmacokinet       Date:  1985 Jul-Aug       Impact factor: 6.447

4.  Risks of jet injection of insulin in children.

Authors:  G E Theintz; P C Sizonenko
Journal:  Eur J Pediatr       Date:  1991-06       Impact factor: 3.183

Review 5.  Ultrafast-acting insulins: state of the art.

Authors:  Lutz Heinemann; Douglas B Muchmore
Journal:  J Diabetes Sci Technol       Date:  2012-07-01

6.  Recombinant DNA derived monomeric insulin analogue: comparison with soluble human insulin in normal subjects.

Authors:  J P Vora; D R Owens; J Dolben; J A Atiea; J D Dean; S Kang; A Burch; J Brange
Journal:  BMJ       Date:  1988-11-12

7.  Aorta and muscle metabolism in pigs with peripheral hyperinsulinaemia.

Authors:  K Falholt; K G Alberti; L G Heding
Journal:  Diabetologia       Date:  1985-01       Impact factor: 10.122

Review 8.  The new insulins. Their characteristics and clinical indications.

Authors:  P D Home; K G Alberti
Journal:  Drugs       Date:  1982-11       Impact factor: 9.546

9.  Long-term comparison of human insulin analogue B10Asp and soluble human insulin in IDDM patients on a basal/bolus insulin regimen.

Authors:  F S Nielsen; L N Jørgensen; M Ipsen; A I Voldsgaard; H H Parving
Journal:  Diabetologia       Date:  1995-05       Impact factor: 10.122

10.  Improved pharmacokinetic and pharmacodynamic profile of rapid-acting insulin using needle-free jet injection technology.

Authors:  Elsemiek E C Engwerda; Evertine J Abbink; Cees J Tack; Bastiaan E de Galan
Journal:  Diabetes Care       Date:  2011-06-29       Impact factor: 19.112
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.