[Role of sex hormones in realizing the monoamine effect on the luliberin content in the hypothalamus].

Drastic decrease in the level of sex hormone in the blood of castrated male rats lessened the content of LH-RH in the arcuate nuclei and median eminence of the hypothalamus. Obviously, this area is the place affected by androgens within the system of the negative feedback mechanism. Intraventricular noradrenaline had a stimulating effect on the synthesis and secretion of LH-RH in both intact and castrated animals. Meanwhile in the absence of sex steroids that action was less powerful. Dopamine stimulated the release of LH-RH from the terminals of the median eminence in all the groups of the animals. In intact animals, serotonin had no effect on the content of LH-RH, while in the castrated animals, it produced an inhibitory action on the synthesis and secretion of LH-RH. The results indicate that the intensity and the line of the effects of monoamines under study may depend to a certain extent on the animals endocrine status. The effects of monoamines on LH-RH neurones is steroid-dependent.