Literature DB >> 704660

Evaluation of antiulcer activity of delta9-tetrahydrocannabinol in the Shay rat test.

R D Sofia, W Diamantis, J E Harrison, J Melton.   

Abstract

delta9-Tetrahydrocannabinol (THC) inhibited ulcer formation in the pylorus-ligated rat (Shay rat test). However, this antiulcer activity of THC was substantially less than for the anticholinergic substance tridihexethyl chloride both in terms of degree of activity and potency. In addition, the results of the present study suggested different mechanism(s) of action for the antiulcer effects of these substances.

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Year:  1978        PMID: 704660     DOI: 10.1159/000136851

Source DB:  PubMed          Journal:  Pharmacology        ISSN: 0031-7012            Impact factor:   2.547


  6 in total

Review 1.  Cannabinoids and the gastrointestinal tract.

Authors:  R G Pertwee
Journal:  Gut       Date:  2001-06       Impact factor: 23.059

Review 2.  The endocannabinoid system as an emerging target of pharmacotherapy.

Authors:  Pál Pacher; Sándor Bátkai; George Kunos
Journal:  Pharmacol Rev       Date:  2006-09       Impact factor: 25.468

3.  Effects of cannabinoid receptor agonists on rat gastric acid secretion: discrepancy between in vitro and in vivo data.

Authors:  Gabriella Coruzzi; Maristella Adami; Elena Guaita; Alessandro Menozzi; Simone Bertini; Elena Giovannini; Giulio Soldani
Journal:  Dig Dis Sci       Date:  2006-02       Impact factor: 3.199

4.  Acute Δ(9)-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice.

Authors:  Steven G Kinsey; Erica C Cole
Journal:  Eur J Pharmacol       Date:  2013-06-11       Impact factor: 4.432

5.  CB1 positive allosteric modulation attenuates Δ9-THC withdrawal and NSAID-induced gastric inflammation.

Authors:  K R Trexler; M L Eckard; S G Kinsey
Journal:  Pharmacol Biochem Behav       Date:  2018-12-28       Impact factor: 3.533

Review 6.  Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation.

Authors:  Klára Gyires; Zoltán S Zádori
Journal:  Curr Neuropharmacol       Date:  2016       Impact factor: 7.363

  6 in total

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