Glycosaminoglycan synthesis by human diabetic, normal adult, and embryonic fibroblasts in relation to insulin levels.

Sulfated glycosaminoglycan synthesis by human diabetic, non-diabetic, and embryonic cells was studied. No effect of insulin on net synthesis was noted. Thus, the data do not indicate a role for total sulfated glycosaminoglycan production in the diabetic connective tissue disturbance mediated by insulin.