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Literature DB >> 7044629

Thyroid antibodies are produced by thyroid-derived lymphocytes.

A P Weetman, A M McGregor, J H Lazarus, R Hall.

Abstract

The significance of the characteristic lymphocytic infiltrate in the target organ in organ-specific autoimmune disease is unknown. We have demonstrated the production of thyroglobulin antibodies and immunoglobulins (IgG, IgM and IgA) by thyroid-derived lymphocytes in Graves' disease and Hashimoto's thyroiditis two plaque forming cell (PFC) assays. The thyroid appears to be an important site of thyroglobulin antibody production but the thyroid lymphocytes also contain many IgG PFCs of non-thyroglobulin specificity. Short-term culture and direct thyroglobulin antibody assay on micro-ELISA plates confirmed the results of the PFC assay. Therapies such as carbimazole may therefore be acting on a localized source of autoantibody production.

Entities: Chemical Disease

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Year: 1982 PMID： 7044629 PMCID： PMC1536583

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

12 in total

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Authors: T H Tötterman
Journal: Clin Immunol Immunopathol Date: 1978-07

Review 2. Induction of antibody synthesis in human B lymphocytes by different polyclonal B cell activators: evaluation by direct and indirect PFC assays.

Authors: O Ringdén; B Rynnel-Dagöö; T Kunori; C I Smith; L Hammarström; A Freijd; E Möller
Journal: Immunol Rev Date: 1979 Impact factor: 12.988

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Authors: S M McLachlan; A McGregor; B R Smith; R Hall
Journal: Lancet Date: 1979-01-20 Impact factor: 79.321

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Authors: E Gronowicz; A Coutinho; F Melchers
Journal: Eur J Immunol Date: 1976-08 Impact factor: 5.532

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Authors: A S Fauci
Journal: J Allergy Clin Immunol Date: 1980-07 Impact factor: 10.793

6. The protein-A plaque assay: a new system for the detection of cells secreting a given idiotype.

Authors: L Hammarström; C I Smith; D Pettersson; H Mellstedt; G Holm
Journal: J Immunol Date: 1980-01 Impact factor: 5.422

7. Carbimazole and the autoimmune response in Graves' disease.

Authors: A M McGregor; M M Petersen; S M McLachlan; P Rooke; B R Smith; R Hall
Journal: N Engl J Med Date: 1980-08-07 Impact factor: 91.245

8. Relation of thyroid-stimulating immunoglobulins to thyroid function and effects of surgery, radioiodine, and antithyroid drugs.

Authors: E D Mukhtar; B R Smith; G A Pyle; R Hall; P Vice
Journal: Lancet Date: 1975-03-29 Impact factor: 79.321

9. Use of plaque assays to study thyroglobulin autoantibody synthesis by human peripheral blood lymphocytes.

Authors: S M McLachlan; A G Bird; A P Weetman; R Smith; R Hall
Journal: Scand J Immunol Date: 1981-09 Impact factor: 3.487

10. Analysis by a plaque assay of IgG- or IgM- dependent cytolytic lymphocytes in human blood.

Authors: B Wåhlin; H Perlmann; P Perlmann
Journal: J Exp Med Date: 1976-11-02 Impact factor: 14.307

23 in total

1. Studies on the immunoregulation of thyroid autoantibody production in vitro.

Authors: P Benveniste; V V Row; R Volpé
Journal: Clin Exp Immunol Date: 1985-08 Impact factor: 4.330

2. Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases.

Authors: Tiphaine C Martin; Mirna Šimurina; Marta Ząbczyńska; Marina Martinic Kavur; Magdalena Rydlewska; Marija Pezer; Kamila Kozłowska; Andrea Burri; Marija Vilaj; Renata Turek-Jabrocka; Milena Krnjajić-Tadijanović; Małgorzata Trofimiuk-Müldner; Ivo Ugrina; Anna Lityńska; Alicja Hubalewska-Dydejczyk; Irena Trbojevic-Akmacic; Ee Mun Lim; John P Walsh; Ewa Pocheć; Tim D Spector; Scott G Wilson; Gordan Lauc
Journal: Mol Cell Proteomics Date: 2020-02-05 Impact factor: 5.911

3. Heterogeneity of the immune status concerning anti-thyroglobulin antibody production among patients with Hashimoto's thyroiditis; an in vitro study.

Authors: T Sekino; Y Shishiba; B Inatsuki; J Yata
Journal: Clin Exp Immunol Date: 1988-06 Impact factor: 4.330

4. Subpopulations of thyroid autoantibody secreting lymphocytes in Graves' and Hashimoto thyroid glands.

Authors: S M McLachlan; C A Pegg; M C Atherton; S L Middleton; A Dickinson; F Clark; S J Proctor; G Proud; B Rees Smith
Journal: Clin Exp Immunol Date: 1986-08 Impact factor: 4.330

5. Functional analysis of T and B cells from blood and thyroid tissue in Hashimoto's disease.

Authors: S M McLachlan; G Proud; C A Pegg; F Clark; B Rees Smith
Journal: Clin Exp Immunol Date: 1985-03 Impact factor: 4.330

6. Thyroid stimulating immunoglobulin (TSI) synthesis by pokeweed mitogen (PWM) stimulated peripheral blood lymphocytes (PBL) from Graves' disease (GD) patients.

Authors: B Pautard; J J Rémy; J Charreire
Journal: Clin Exp Immunol Date: 1986-11 Impact factor: 4.330

7. The presence of higher levels of thyroglobulin, but not thyroid autoantibodies, in the thyroid vein in Graves' disease.

Authors: F F Chou; P W Wang; S M Sheen-Chen
Journal: J Endocrinol Invest Date: 1994-01 Impact factor: 4.256