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Literature DB >> 7044294

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine.

Abstract

A total of 52 healthy, adult volunteers were randomly assigned to five treatment groups to be treated twice daily for 4 days with 100 mg of amantadine, 100 mg of rimantadine, 4 mg of chlorpheniramine or placebo alone, or 100 mg of amantadine in combination with chlorpheniramine. The results of tests measuring performance on tasks of attention, reasoning, and memory were unaffected by treatment. Subjective side effects in recipients of amantadine, rimantadine, and chlorpheniramine were comparable and minimal. Side effects appeared to be enhanced in subjects receiving both amantadine and chlorpheniramine.

Entities: Chemical

Mesh：

Substances：

Year: 1982 PMID： 7044294 PMCID： PMC181819 DOI： 10.1128/AAC.21.1.1

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. Prevention and control of influenza by chemoprophylaxis and chemotherapy. Prospects from examination of recent experience.

Authors: G G Jackson; E D Stanley
Journal: JAMA Date: 1976-06-21 Impact factor: 56.272

2. From the National Institutes of Health. Report of a workshop on clinical studies of the efficacy of amantadine and rimantadine against influenza vireus.

Authors: J R LaMontagne; G J Galasso
Journal: J Infect Dis Date: 1978-12 Impact factor: 5.226

3. Evaluation of amantadine in artificially induced A2 and B influenza.

Authors: A A Smorodintsev; D M Zlydnikov; A M Kiseleva; J A Romanov; A P Kazantsev; V I Rumovsky
Journal: JAMA Date: 1970-08-31 Impact factor: 56.272

4. The effect of marihuana on tracking task performance.

Authors: W T Roth; J R Tinklenberg; C A Whitaker; C F Darley; B S Kopell; L E Hollister
Journal: Psychopharmacologia Date: 1973

5. Therapeutic efficacy of amantadine HCl and rimantadine HCl in naturally occurring influenza A2 respiratory illness in man.

Authors: W L Wingfield; D Pollack; R R Grunert
Journal: N Engl J Med Date: 1969-09-11 Impact factor: 91.245

6. Treatment of influenza. The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak.

Authors: S Rabinovich; J T Baldini; R Bannister
Journal: Am J Med Sci Date: 1969-05 Impact factor: 2.378

7. Amantadine intoxication reversed by physostigmine.

Authors: D E Casey
Journal: N Engl J Med Date: 1978-03-02 Impact factor: 91.245

8. A prospective double-blind study of side effects associated with the administration of amantadine for influenza A virus prophylaxis.

Authors: Y J Bryson; C Monahan; M Pollack; W D Shields
Journal: J Infect Dis Date: 1980-05 Impact factor: 5.226

9. A component analysis of attentional problems of educationally handicapped boys.

Authors: B K Keogh; J S Margolis
Journal: J Abnorm Child Psychol Date: 1976

10. Prevention of Russian influenza by amantadine.

Authors: A S Monto; R A Gunn; M G Bandyk; C L King
Journal: JAMA Date: 1979-03-09 Impact factor: 56.272

10 in total

Review 1. Amantadine and rimantadine for influenza A in adults.

Authors: T Jefferson; V Demicheli; C Di Pietrantonj; D Rivetti
Journal: Cochrane Database Syst Rev Date: 2006-04-19

Review 2. Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials.

Authors: Nicola J Cooper; Alexander J Sutton; Keith R Abrams; Allan Wailoo; David Turner; Karl G Nicholson
Journal: BMJ Date: 2003-06-07

Review 10. Antiviral agents.

Authors: E D Reines; P A Gross
Journal: Med Clin North Am Date: 1988-05 Impact factor: 5.456

10 in total

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine.

1. Prevention and control of influenza by chemoprophylaxis and chemotherapy. Prospects from examination of recent experience.

2. From the National Institutes of Health. Report of a workshop on clinical studies of the efficacy of amantadine and rimantadine against influenza vireus.

3. Evaluation of amantadine in artificially induced A2 and B influenza.

4. The effect of marihuana on tracking task performance.

5. Therapeutic efficacy of amantadine HCl and rimantadine HCl in naturally occurring influenza A2 respiratory illness in man.

6. Treatment of influenza. The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak.

7. Amantadine intoxication reversed by physostigmine.

8. A prospective double-blind study of side effects associated with the administration of amantadine for influenza A virus prophylaxis.

9. A component analysis of attentional problems of educationally handicapped boys.

10. Prevention of Russian influenza by amantadine.

Review 1. Amantadine and rimantadine for influenza A in adults.

Review 2. Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials.

Review 3. Neuropsychiatric adverse effects of antiparkinsonian drugs. Characteristics, evaluation and treatment.

4. Amantadine for adynamic speech: possible benefit for aphasia?

Review 5. Amantadine and rimantadine prophylaxis of influenza A in nursing homes. A tolerability perspective.

Review 6. Antiviral chemotherapy and prophylaxis of viral respiratory disease.

Review 7. The future of antiviral chemotherapy.

8. Chapter 12. Antiviral Agents.

9. Chapter 7 Orthomyxovirus infections.

Review 10. Antiviral agents.