Literature DB >> 7042914

Identification of a cholinergic-specific antigen Chol-1 as a ganglioside.

P J Richardson, J H Walker, R T Jones, V P Whittaker.   

Abstract

An antiserum specific for cholinergic terminals was used to identify an antigen conserved between Elasmobranchs and mammals. Immunohistochemistry and a cytotoxicity test were used to assay the binding of antibody to mammalian terminals. Torpedo electric organ gangliosides totally abolished antibody binding. The highest inhibitory activity was associated with a single polysialoganglioside band on TLC plates. Neuraminidase altered the migration of the inhibitory activity on TLC plates. Antibody binding was inhibited by ganglioside fractions derived from chicken and mammalian brains. A summary of those tissues in which the antigen has been detected is presented. The possible function of the antigen is discussed.

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Year:  1982        PMID： 7042914     DOI： 10.1111/j.1471-4159.1982.tb06640.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  21 in total

1.  Adenosine receptors in post-mortem human brain.

Authors:  S James; J H Xuereb; R Askalan; P J Richardson
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

2.  An immunohistochemical study of synaptogenesis in the electric organ of Torpedo marmorata by use of antisera to vesicular and presynaptic plasma membrane components.

Authors:  W Fiedler; E Borroni; P Ferretti
Journal:  Cell Tissue Res       Date:  1986       Impact factor: 5.249

3.  Cholinergic function in the nineties: advantages of work with a model system.

Authors:  V P Whittaker
Journal:  Neurochem Res       Date:  1987-02       Impact factor: 3.996

4.  Immunoaffinity purification of intact, metabolically active, cholinergic nerve terminals from mammalian brain.

Authors:  P J Richardson; K Siddle; J P Luzio
Journal:  Biochem J       Date:  1984-04-15       Impact factor: 3.857

Review 5.  Evolutionary approach to the analysis of structure and function of gangliosides.

Authors:  N F Avrova
Journal:  Neurochem Res       Date:  1985-11       Impact factor: 3.996

6.  Ganglioside metabolism in a transgenic mouse model of Alzheimer's disease: expression of Chol-1α antigens in the brain.

Authors:  Toshio Ariga; Makoto Yanagisawa; Chandramohan Wakade; Susumu Ando; Jerry J Buccafusco; Michael P McDonald; Robert K Yu
Journal:  ASN Neuro       Date:  2010-10-04       Impact factor: 4.146

7.  Binding of botulinum neurotoxin to pure cholinergic nerve terminals isolated from the electric organ of Torpedo.

Authors:  J Blasi; G Egea; M J Castiella; M Arribas; C Solsona; P J Richardson; J Marsal
Journal:  J Neural Transm Gen Sect       Date:  1992

Review 8.  The Pathogenic Role of Ganglioside Metabolism in Alzheimer's Disease-Cholinergic Neuron-Specific Gangliosides and Neurogenesis.

Authors:  Toshio Ariga
Journal:  Mol Neurobiol       Date:  2017-01       Impact factor: 5.590

9.  Immunocytochemical evaluation of a cholinergic-specific ganglioside antigen (Chol-1) in the central nervous system of the rat.

Authors:  J Obrocki; E Borroni
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

10.  Gangliosides in acetylcholine receptor-rich membranes from Torpedo marmorata and Discopyge tschudii.

Authors:  V Marcheselli; J L Daniotti; A C Vidal; H Maccioni; D Marsh; F J Barrantes
Journal:  Neurochem Res       Date:  1993-05       Impact factor: 3.996
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