Literature DB >> 7042846

The presence of sialic acid on two related bacterial polysaccharides determines the site of the primary immune response and the effect of complement depletion on the response in mice.

R B Markham, A Nicholson-Weller, G Schiffman, D L Kasper.   

Abstract

We have examined the antibody responses in mice to two structurally similar antigens: the capsular polysaccharide of type 3 group B streptococci (sssGBS 3) and the capsular polysaccharide of type 14 pneumococci (sssPn 14), which differ only in the presence of a terminal sialic acid on the side chain of the former. The cells that produce antibody to the nonsialated antigen (sssPn 14) reside in the spleen, whereas the cells that produce antibody to the sialated antigen (sssGBS 3) do not. Cobra venom factor treatment of the mice before immunization abrogates the antibody response to the nonsialated antigen, but does not affect the response to the sialated antigen.

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Year:  1982        PMID： 7042846

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  12 in total

1.  Gonococcal lipooligosaccharide sialylation prevents complement-dependent killing by immune sera.

Authors:  L M Wetzler; K Barry; M S Blake; E C Gotschlich
Journal:  Infect Immun       Date:  1992-01       Impact factor: 3.441

2.  Depletion of complement has distinct effects on the primary and secondary antibody responses to a conjugate of pneumococcal serotype 14 capsular polysaccharide and a T-cell-dependent protein carrier.

Authors:  Samuel T Test; Joyce K Mitsuyoshi; Yong Hu
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

3.  A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links Heptose II Lactose Expression with Pathogenicity.

Authors:  Sanjay Ram; Sunita Gulati; Lisa A Lewis; Srinjoy Chakraborti; Bo Zheng; Rosane B DeOliveira; George W Reed; Andrew D Cox; Jianjun Li; Frank St Michael; Jacek Stupak; Xiao-Hong Su; Sudeshna Saha; Corinna S Landig; Ajit Varki; Peter A Rice
Journal:  Infect Immun       Date:  2018-07-23       Impact factor: 3.441

4.  In vitro complement-dependent binding and in vivo kinetics of pneumococcal polysaccharide TI-2 antigens in the rat spleen marginal zone and follicle.

Authors:  G Harms; M J Hardonk; W Timens
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

5.  Immunoregulatory role of the spleen in antibody responses to pneumococcal polysaccharide antigens.

Authors:  D A Cohn; G Schiffman
Journal:  Infect Immun       Date:  1987-06       Impact factor: 3.441

6.  Synthesis and immunological properties of conjugates composed of group B streptococcus type III capsular polysaccharide covalently bound to tetanus toxoid.

Authors:  T Lagergard; J Shiloach; J B Robbins; R Schneerson
Journal:  Infect Immun       Date:  1990-03       Impact factor: 3.441

7.  Increased immunogenicity and induction of class switching by conjugation of complement C3d to pneumococcal serotype 14 capsular polysaccharide.

Authors:  S T Test; J Mitsuyoshi; C C Connolly; A H Lucas
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

8.  Capsular antibodies induce type-specific phagocytosis of capsulated Staphylococcus aureus by human polymorphonuclear leukocytes.

Authors:  W W Karakawa; A Sutton; R Schneerson; A Karpas; W F Vann
Journal:  Infect Immun       Date:  1988-05       Impact factor: 3.441

9.  CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.

Authors:  Karen M Haas; Jonathan C Poe; Thomas F Tedder
Journal:  J Immunol       Date:  2009-08-26       Impact factor: 5.422

10.  Characterization of the antibody response in inbred mice to a high-molecular-weight polysaccharide from Pseudomonas aeruginosa immunotype 1.

Authors:  R B Markham; G B Pier
Journal:  Infect Immun       Date:  1983-07       Impact factor: 3.441
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