Literature DB >> 7042381

Captopril(SQ 14,225): in vitro and in vivo influence on the proliferative response of rat lymphocytes.

L Binderup, E Bramm, E Arrigoni-Martelli.   

Abstract

Captopril in vitro (50-500 micrograms/ml) increased 3H-TdR incorporation in unstimulated and mitogen-stimulated cultures of rat lymphocytes. Unseparated spleen and lymph node cells of rats orally treated with captopril (50 mg/kg/day x 4)) showed decreased basal and mitogen stimulated 3H-TdR incorporation. The removal of macrophages abrogated this inhibitory effect. Leucine aminopeptidase activity of macrophages was reduced - in vivo and in vitro - by captopril.

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Year:  1982        PMID： 7042381     DOI： 10.1007/bf01949416

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Bestatin, a new specific inhibitor of aminopeptidases, enhances activation of small lymphocytes by concanavalin A.

Authors:  M Saito; T Aoyagi; H Umezawa; Y Nagai
Journal:  Biochem Biophys Res Commun       Date:  1976-05-23       Impact factor: 3.575

2.  Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer.

Authors:  H Suda; T Aoyagi; T Takeuchi; H Umezawa
Journal:  Arch Biochem Biophys       Date:  1976-11       Impact factor: 4.013

3.  Enhancement of delayed-type hypersensitivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase.

Authors:  H Umezawa; M Ishizuka; T Aoyagi; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1976-08       Impact factor: 2.649

4.  Cytochemical identification of monocytes and granulocytes.

Authors:  L T Yam; C Y Li; W H Crosby
Journal:  Am J Clin Pathol       Date:  1971-03       Impact factor: 2.493

5.  Immunological effects of D-penicillamine during experimental induced inflammation in rats.

Authors:  L Binderup; E Bramm; E Arrigoni-Martelli
Journal:  Scand J Immunol       Date:  1980       Impact factor: 3.487

6.  Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes.

Authors:  J D Broome; M W Jeng
Journal:  J Exp Med       Date:  1973-09-01       Impact factor: 14.307

7.  Restoration of impaired immune functions of aged animals by chronic bestatin treatment.

Authors:  M Bruley-Rosset; I Florentin; N Kiger; J Schulz; G Mathé
Journal:  Immunology       Date:  1979-09       Impact factor: 7.397

8.  Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. Changes with mitogen dose and preincubation.

Authors:  J S Goodwin; R P Messner; G T Peake
Journal:  J Clin Invest       Date:  1978-10       Impact factor: 14.808

9.  Captopril-induced changes in prostaglandin production: relationship to vascular responses in normal man.

Authors:  S L Swartz; G H Williams; N K Hollenberg; L Levine; R G Dluhy; T J Moore
Journal:  J Clin Invest       Date:  1980-06       Impact factor: 14.808

10.  Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol.

Authors:  M G Goodman; W O Weigle
Journal:  J Exp Med       Date:  1977-03-01       Impact factor: 14.307
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  3 in total

1.  A rat model of captopril immunogenicity.

Authors:  A L Foster; J W Coleman
Journal:  Clin Exp Immunol       Date:  1989-01       Impact factor: 4.330

2.  Drug-specific antibodies in patients receiving captopril.

Authors:  J W Coleman; J H Yeung; D H Roberts; A M Breckenridge; B K Park
Journal:  Br J Clin Pharmacol       Date:  1986-08       Impact factor: 4.335

3.  Captopril enhances in vitro human lymphocyte thymidine incorporation.

Authors:  M R Simon; J V Weinstock; R M Morrell; L D Roi; L M Howard
Journal:  Agents Actions       Date:  1984-12
  3 in total

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