Literature DB >> 7042316

Evidence for two species of insulin-like growth factor II (IGF II and "big" IGF II) in human spinal fluid.

G Haselbacher, R Humbel.   

Abstract

Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts. In addition, an IGF II of larger mass could be detected by a radioimmunoassay for IGF II. This "big" IGF II is biologically active and has an apparent molecular weight of 9000.

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Year:  1982        PMID： 7042316     DOI： 10.1210/endo-110-5-1822

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  19 in total

Review 1.  Molecular biology of the insulin-like growth factors. Relevance to nervous system function.

Authors:  J E Hepler; P K Lund
Journal:  Mol Neurobiol       Date:  1990 Spring-Summer       Impact factor: 5.590

Review 2.  Somatomedins: chemical and functional characteristics of the different molecular forms.

Authors:  A Barreca; F Minuto
Journal:  J Endocrinol Invest       Date:  1989-04       Impact factor: 4.256

3.  Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

Authors:  F Stylianopoulou; J Herbert; M B Soares; A Efstratiadis
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

4.  Amino acid sequence of a variant pro-form of insulin-like growth factor II.

Authors:  P P Zumstein; C Lüthi; R E Humbel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

5.  Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

Authors:  G K Haselbacher; J C Irminger; J Zapf; W H Ziegler; R E Humbel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

Review 6.  Insulin and insulin-like growth factor receptors in the nervous system.

Authors:  M Adamo; M K Raizada; D LeRoith
Journal:  Mol Neurobiol       Date:  1989 Spring-Summer       Impact factor: 5.590

7.  Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions.

Authors:  J C Irminger; K M Rosen; R E Humbel; L Villa-Komaroff
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

8.  Insulin-like growth factors and insulin: comparative aspects.

Authors:  E R Froesch; J Zapf
Journal:  Diabetologia       Date:  1985-08       Impact factor: 10.122

9.  Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?

Authors:  J Zapf; E Futo; M Peter; E R Froesch
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

10.  Comparative binding of bovine, human and rat insulin-like growth factors to membrane receptors and to antibodies against human insulin-like growth factor-1.

Authors:  L C Read; F J Ballard; G L Francis; R C Baxter; C J Bagley; J C Wallace
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857
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