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Literature DB >> 7041818

Metabolism of verruculogen in rats.

K P Perera, J B Day, P G Mantle, L Rodrigues.

Abstract

Radiolabeled verruculogen was detected in a wide range of body tissues 6 min after intravenous administration, but after a further 20 min it was mainly being excreted via the biliary route. In isolated liver perfusion, [14C]verruculogen was rapidly taken up by the liver and metabolized completely, principally to the related tremorgen TR-2 but also to a desoxy derivative of verruculogen. In addition, a smaller amount of an isomer of TR-2 was detected. These metabolic products were excreted in the bile.

Entities: Gene Species

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Year: 1982 PMID： 7041818 PMCID： PMC241864 DOI： 10.1128/aem.43.3.503-508.1982

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

7 in total

1. Structure of the tremor-producing indole, TR-2.

Authors: R J Cole; J W Kirksey; R H Cox; J Clardy
Journal: J Agric Food Chem Date: 1975 Sep-Oct Impact factor: 5.279

2. Biosynthesis of radiolabeled verruculogen by Penicillium simplicissimum.

Authors: J B Day; P G Mantle
Journal: Appl Environ Microbiol Date: 1982-03 Impact factor: 4.792

3. Production of verruculogen by Penicillium estinogenum in stirred fermenters.

Authors: J B Day; P G Mantle; B I Shaw
Journal: J Gen Microbiol Date: 1980-04

4. Biosynthesis of [14C]zearalenone from [1-14C]acetate by Fusarium roseum 'Gibbosum'.

Authors: W M Hagler; C J Mirocha
Journal: Appl Environ Microbiol Date: 1980-03 Impact factor: 4.792

5. Formation of 4-hydroxyochratoxin A from ochratoxin A by rat liver microsomes.

Authors: F C Størmer; J I Pedersen
Journal: Appl Environ Microbiol Date: 1980-05 Impact factor: 4.792

6. Gluconeogenesis in the perfused rat liver.

Authors: R Hems; B D Ross; M N Berry; H A Krebs
Journal: Biochem J Date: 1966-11 Impact factor: 3.857

7. Biosynthesis of radiolabeled T-2 toxin by Fusarium tricinctum.

Authors: W M Hagler; C J Mirocha; S V Pathre
Journal: Appl Environ Microbiol Date: 1981-04 Impact factor: 4.792

7 in total

4 in total

Metabolism of verruculogen in rats.

1. Structure of the tremor-producing indole, TR-2.

2. Biosynthesis of radiolabeled verruculogen by Penicillium simplicissimum.

3. Production of verruculogen by Penicillium estinogenum in stirred fermenters.

4. Biosynthesis of [14C]zearalenone from [1-14C]acetate by Fusarium roseum 'Gibbosum'.

5. Formation of 4-hydroxyochratoxin A from ochratoxin A by rat liver microsomes.

6. Gluconeogenesis in the perfused rat liver.

7. Biosynthesis of radiolabeled T-2 toxin by Fusarium tricinctum.

1. In vitro transformation of the tremorgenic mycotoxin verruculogen.

2. An intermediary role for the tremorgenic mycotoxin TR-2 in the biosynthesis of verruculogen.

3. Tremorgenic mycotoxins from Aspergillus fumigatus as a possible occupational health problem in sawmills.

4. Growth of and fumitremorgin production by Neosartorya fischeri as affected by temperature, light, and water activity.