Literature DB >> 7041599

Comparison of antihypertensive and hormonal effects of captopril and propranolol at rest and during exercise.

T G Pickering, D B Case, P A Sullivan, J H Laragh.   

Abstract

Captopril and propranolol were given alone and in combination to 13 hypertensive men and the effects studied at rest (seated, supine and standing) and during exercise. The two drugs were equipotent at rest, and individual patients showed similar blood pressure responses to the two drugs. Both produced slight reduction of urinary aldosterone; when given in combination, both blood pressure and aldosterone were further reduced. During exercise the increase in blood pressure was unaffected by captopril but reduced by propranolol, and there was no correlation between individual responses to the two drugs. It is concluded that the similar effects of the two drugs on resting blood pressure are consistent with their effects on the renin-angiotensin system.

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Year:  1982        PMID： 7041599     DOI： 10.1016/0002-9149(82)90392-7

Source DB:  PubMed          Journal:  Am J Cardiol        ISSN： 0002-9149            Impact factor:   2.778


  10 in total

1.  The effects of combined angiotensin converting enzyme inhibition and beta-adrenoceptor blockade on plasma renin activity in anaesthetized dogs.

Authors:  D Cambridge; M V Whiting; L J Butterfield; G Allan
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

2.  Hemodynamic effects of celiprolol at rest and during exercise; a comparison with enalapril.

Authors:  S Ghiringhelli; E Cozzi; D Tsialtas
Journal:  Cardiovasc Drugs Ther       Date:  1988-07       Impact factor: 3.727

Review 3.  Captopril. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure.

Authors:  R N Brogden; P A Todd; E M Sorkin
Journal:  Drugs       Date:  1988-11       Impact factor: 9.546

Review 4.  Low dose combination antihypertensive therapy. Additional efficacy without additional adverse effects?

Authors:  A M MacConnachie; D Maclean
Journal:  Drug Saf       Date:  1995-02       Impact factor: 5.606

Review 5.  ACE inhibitors. Drug interactions of clinical significance.

Authors:  C Mignat; T Unger
Journal:  Drug Saf       Date:  1995-05       Impact factor: 5.606

6.  Enalapril versus combined enalapril and nadolol treatment: effects on blood pressure, heart rate, humoral variables, and plasma potassium at rest and during exercise in hypertensive patients.

Authors:  P A Sullivan; B Daly; R O'Connor
Journal:  Cardiovasc Drugs Ther       Date:  1992-06       Impact factor: 3.727

7.  Fosenopril, an angiotensin-converting enzyme inhibitor, and propranolol: comparative effects at rest and exercise on blood pressure, hormonal variables, and plasma potassium in essential hypertension.

Authors:  P A Sullivan; J Cervenka; D T O'Connor; M Dineen
Journal:  Cardiovasc Drugs Ther       Date:  1989-03       Impact factor: 3.727

8.  BW A575C, a chemically novel agent with angiotensin converting enzyme inhibitor and beta-adrenoceptor-blocking properties.

Authors:  G Allan; D Cambridge; G W Hardy; M J Follenfant
Journal:  Br J Pharmacol       Date:  1987-03       Impact factor: 8.739

9.  Effects of ACE inhibition on endurance exercise haemodynamics in trained subjects with mild hypertension.

Authors:  P Palatini; S Bongiovi; L Mario; P Mormino; G Raule; A C Pessina
Journal:  Eur J Clin Pharmacol       Date:  1995       Impact factor: 2.953

10.  Cardiac and renovascular effects in the anaesthetized dog of BW A575C: a novel angiotensin converting enzyme inhibitor with beta-adrenoceptor blocking properties.

Authors:  D Cambridge; M V Whiting; G Allan
Journal:  Br J Pharmacol       Date:  1988-01       Impact factor: 8.739
  10 in total

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