Literature DB >> 7041568

Effect of synthetic PAF-acether on human neutrophil function.

B M Czarnetzki, J Benveniste.   

Abstract

Synthetic PAF-acether was studied for its effect on human neutrophil migration and secretion. Based on checkerboard analysis, the factor is chemokinetic for neutrophils, but it also enhances ECF-stimulated chemotaxis. By itself, PAF-acether does not induce ECF or beta-glucuronidase secretion from neutrophils, but it causes a dose-dependent enhancement of release in the presence of zymosan. PAF-acether thus potentially modulates neutrophil functions during inflammatory events.

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Year:  1981        PMID： 7041568     DOI： 10.1007/bf01978734

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  Release of eosinophil chemotactic factor from human polymorphonuclear neutrophils by calcium ionophore A23187 and phagocytosis.

Authors:  B M Gzarnetzki; W Konig; L M Lichtenstein
Journal:  Nature       Date:  1975-12-25       Impact factor: 49.962

2.  A new approach to anti-inflammatory drugs.

Authors:  G A Higgs; R J Flower; J R Vane
Journal:  Biochem Pharmacol       Date:  1979-06-15       Impact factor: 5.858

3.  Structural analysis of purified platelet-activating factor by lipases.

Authors:  J Benveniste; J P Le Couedic; J Polonsky; M Tence
Journal:  Nature       Date:  1977-09-08       Impact factor: 49.962

4.  Leukotriene B: a potential mediator of inflammation.

Authors:  M J Smith; A W Ford-Hutchinson; M A Bray
Journal:  J Pharm Pharmacol       Date:  1980-07       Impact factor: 3.765

5.  Neutrophil-derived eosinophil chemotactic factor production induced by immune complexes.

Authors:  B M Czarnetzki; W Schulz
Journal:  Int Arch Allergy Appl Immunol       Date:  1981

6.  Platelet activating factor (PAF-acether): total synthesis of 1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphoryl choline.

Authors:  J J Godfroid; F Heymans; E Michel; C Redeuilh; E Steiner; J Benveniste
Journal:  FEBS Lett       Date:  1980-07-28       Impact factor: 4.124

7.  Platelet activating factor: an inhibitor of neutrophil activation?

Authors:  M C O'Donnell; J N Siegel; B A Fiedel
Journal:  Clin Exp Immunol       Date:  1981-01       Impact factor: 4.330

8.  Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

Authors:  R C Murphy; S Hammarström; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

9.  Platelet-activating factor in anaphylaxis and phagocytosis. I. Release from human peripheral polymorphonuclears and monocytes during the stimulation by ionophore A23187 and phagocytosis but not from degranulating basophils.

Authors:  M Sánchez-Crespo; F Alonso; J Egido
Journal:  Immunology       Date:  1980-08       Impact factor: 7.397
  9 in total
  5 in total

1.  Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects.

Authors:  N M Roberts; M McCusker; K F Chung; P J Barnes
Journal:  Br J Clin Pharmacol       Date:  1988-07       Impact factor: 4.335

Review 2.  Biology and biochemistry of platelet-activating factor.

Authors:  J T O'Flaherty; R L Wykle
Journal:  Clin Rev Allergy       Date:  1983-09

3.  Platelet-activating factor (PAF-acether), an activator of neutrophil functions.

Authors:  E Jouvin-Marche; B Poitevin; J Benveniste
Journal:  Agents Actions       Date:  1982-12

4.  Inhaled budesonide fails to inhibit the PAF-induced increase in plasma leukotriene B4 in man.

Authors:  M M Nieminen; E K Moilanen; M O Koskinen; J I Karvonen; L Tuomisto; T J Metsä-Ketelä; H Vapaatalo
Journal:  Br J Clin Pharmacol       Date:  1992-06       Impact factor: 4.335

5.  The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia.

Authors:  Ana T Guerrero; Ana C Zarpelon; Ana C Zaperlon; Silvio M Vieira; Larissa G Pinto; Sérgio H Ferreira; Fernando Q Cunha; Waldiceu A Verri; Thiago M Cunha
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2012-11-28       Impact factor: 3.000
  5 in total

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