Experimental models of atherosclerosis (the insudative theory).

Atherosclerosis, a disease of multifactorial origin, can be promoted or caused experimentally by a wide variety of methods. The leading role of altered endothelial permeability, as well as different experimental techniques for producing changes in permeability, have been discussed by selecting the insudative theory as a working hypothesis. An attempt has been made to prove that by altering the endothelial permeability with different types of injuries, atherosclerotic vascular damage can be provoked with or without hypercholesterolemia.