Literature DB >> 7040511

Toxicology, carcinogenicity, and teratogenicity of some orally administered retinoids.

J J Kamm.   

Abstract

This paper is a review of the acute, subchronic, and chronic toxicity, mutagenicity, carcinogenicity, and teratogenicity of vitamin A, tretinoin (all-trans-retinoic acid), isotretinoin (13-cis-retinoic acid), and etretinate. The results of in vitro mutagenicity testing of the retinoids are also presented. In addition to teratogenesis studies, experiments designed to evaluate the effects of the retinoids on fertility and reproductive performance and on perinatal and postnatal development are also described.

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Year:  1982        PMID： 7040511     DOI： 10.1016/s0190-9622(82)70054-4

Source DB:  PubMed          Journal:  J Am Acad Dermatol        ISSN： 0190-9622            Impact factor:   11.527


  23 in total

Review 1.  Drug-induced congenital defects: strategies to reduce the incidence.

Authors:  M De Santis; B Carducci; A F Cavaliere; L De Santis; G Straface; A Caruso
Journal:  Drug Saf       Date:  2001       Impact factor: 5.606

2.  Isotretinoin use in severe acne.

Authors:  E W Turgeon
Journal:  Can Fam Physician       Date:  1985-01       Impact factor: 3.275

3.  Limb bud cell cultures for estimating the teratogenic potential of compounds. Validation of the test system with retinoids.

Authors:  A Kistler
Journal:  Arch Toxicol       Date:  1987-08       Impact factor: 5.153

4.  Accutane-induced teratogenesis.

Authors:  R Robertson; P M MacLeod
Journal:  CMAJ       Date:  1985-12-01       Impact factor: 8.262

Review 5.  The retinoids. A review of their clinical pharmacology and therapeutic use.

Authors:  C E Orfanos; R Ehlert; H Gollnick
Journal:  Drugs       Date:  1987-10       Impact factor: 9.546

6.  Teratogenicity of arotinoids (retinoids) in vivo and in vitro.

Authors:  A Kistler; T Tsuchiya; M Tsuchiya; M Klaus
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

7.  The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid.

Authors:  G Tzimas; H Bürgin; M D Collins; H Hummler; H Nau
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

Review 8.  Isotretinoin. A review of its pharmacological properties and therapeutic efficacy in acne and other skin disorders.

Authors:  A Ward; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1984-07       Impact factor: 9.546

Review 9.  Etretinate. A review of its pharmacological properties and therapeutic efficacy in psoriasis and other skin disorders.

Authors:  A Ward; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1983-07       Impact factor: 9.546

10.  Acitretin-associated erectile dysfunction: a case report.

Authors:  Marco Rossi; Michele Pellegrino
Journal:  Cases J       Date:  2009-11-19
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