Literature DB >> 7040362

Activation of kidney prorenin by kidney cathepsin B isozymes.

S Takahashi, K Murakami, Y Miyake.   

Abstract

Kidney protein was converted to a form of active renin by kidney cathepsin B isozymes. The three isozymes showed similar catalytic behavior for prorenin. The optimal pH for the activation was in the range of 4.0-5.0 and the reaction was completely inhibited by leupeptin. The molecular weight and the isoelectric point of the activated prorenin were 40,000 and pH 4.9. As a minor product, an activated prorenin having an isoelectric point of 5.2 was also produced.

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Year:  1982        PMID： 7040362     DOI： 10.1093/oxfordjournals.jbchem.a133705

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  9 in total

1.  Renin processing studied by immunogold localization of prorenin and renin in granular juxtaglomerular cells in mice treated with enalapril.

Authors:  J L Berka; D Alcorn; G B Ryan; S L Skinner
Journal:  Cell Tissue Res       Date:  1992-04       Impact factor: 5.249

2.  Identification of an enzyme in human kidney that correctly processes prorenin.

Authors:  T Shinagawa; Y S Do; J D Baxter; C Carilli; J Schilling; W A Hsueh
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

3.  Cathepsin D coexists with renin in the secretory granules of juxtaglomerular epithelioid cells.

Authors:  R Taugner; S Yokota; C P Bührle; E Hackenthal
Journal:  Histochemistry       Date:  1986

4.  Immunocytochemical localization of cathepsins B and H in human pancreatic endocrine cells and insulinoma cells.

Authors:  B Im; E Kominami; D Grube; Y Uchiyama
Journal:  Histochemistry       Date:  1989

5.  Typical and atypical aspects of renin secretion from juxtaglomerular epithelioid cells.

Authors:  R Taugner; C P Bührle; E Hackenthal; R Nobiling
Journal:  Klin Wochenschr       Date:  1986-09-15

6.  Cathepsin B from human renal cortex.

Authors:  A D Gounaris; E E Slater
Journal:  Biochem J       Date:  1982-08-01       Impact factor: 3.857

7.  Renin activation in juvenile secretory granules? Immunocytochemical experiments with an antiserum directed against the prosegment of human renin.

Authors:  R Taugner; K Murakami; S J Kim
Journal:  Histochemistry       Date:  1986

8.  Coexistence of renin and cathepsin B in epithelioid cell secretory granules.

Authors:  R Taugner; C P Bührle; R Nobiling; H Kirschke
Journal:  Histochemistry       Date:  1985

9.  Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system.

Authors:  Nilima Biswas; Adam X Maihofer; Saiful Anam Mir; Fangwen Rao; Kuixing Zhang; Srikrishna Khandrika; Manjula Mahata; Ryan S Friese; C Makena Hightower; Sushil K Mahata; Dewleen G Baker; Caroline M Nievergelt; Sucheta M Vaingankar; Daniel T O'Connor
Journal:  BMC Med Genet       Date:  2016-03-11       Impact factor: 2.103
  9 in total

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