Literature DB >> 7040252

Antibacterial kinetics of ampicillin against Escherichia coli under simulated in vivo conditions.

J E Fuglesang, T Bergan.   

Abstract

We studied the response of Escherichia coli to ampicillin concentrations which decreased logarithmically at elimination half-life values (t1/2a) ranging from one to four hours. The rate of bacterial killing depended on the initial antibiotic concentration (co), but was not significantly affected by t1/2a. Irrespective of co and t1/2a, the bactericidal effect terminated after about three hours of exposure to the drug.

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Year:  1982        PMID： 7040252     DOI： 10.1007/bf01640835

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  19 in total

Review 1.  Optimal dosage regimen for penicillins: bolus or continuous infusion?

Authors:  L Curcio
Journal:  J Antimicrob Chemother       Date:  1979-09       Impact factor: 5.790

2.  [Bactericidal dosie-activity relationships with E. coli, K. pneumoniae and Staph. aureus (author's transl)].

Authors:  P M Shah; W Stille
Journal:  Dtsch Med Wochenschr       Date:  1976-02-27       Impact factor: 0.628

3.  Analysis of penicillins in biological material by reversed phase liquid chromatography and post-column derivatization.

Authors:  D Westerlund; J Carlqvist; A Theodorsen
Journal:  Acta Pharm Suec       Date:  1979

4.  In vitro model simulating the form of exposure of bacteria to antimicrobial drugs encountered in infection.

Authors:  M J Al-Asadi; D Greenwood; F O'Grady
Journal:  Antimicrob Agents Chemother       Date:  1979-07       Impact factor: 5.191

Review 5.  An in vitro model of the urinary bladder.

Authors:  D Greenwood; F O'Grady
Journal:  J Antimicrob Chemother       Date:  1978-03       Impact factor: 5.790

6.  Kinetics and mechanisms of drug action on microorganisms. XVII. Bactericidal effects of penicillin, kanamycin, and rifampin with and without organism pretreatment with bacteriostatic chloramphenicol, tetracycline, and novobiocin.

Authors:  E R Garrett; C M Won
Journal:  J Pharm Sci       Date:  1973-10       Impact factor: 3.534

7.  [Paradoxic bactericidal effect of penicillins on enterococci (Eagle effect)].

Authors:  W Stille; H Uffelmann
Journal:  Dtsch Med Wochenschr       Date:  1973-03-23       Impact factor: 0.628

8.  An in vitro model for monitoring bacterial responses to antibiotic agents under simulated in vivo conditions.

Authors:  T Bergan; I B Carlsen; J E Fuglesang
Journal:  Infection       Date:  1980       Impact factor: 3.553

9.  Bactericidal activity of cefadroxil, cephalexin, and cephradine in an in vitro pharmacokinetic model.

Authors:  F Leitner; R A Goodhines; R E Buck; K E Price
Journal:  J Antibiot (Tokyo)       Date:  1979-07       Impact factor: 2.649

10.  The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms.

Authors:  H EAGLE; A D MUSSELMAN
Journal:  J Exp Med       Date:  1948-07       Impact factor: 14.307
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  3 in total

1.  Antibacterial activity and kill kinetics of ampicillin/sulbactam (CP-45899) combinations against Escherichia coli and Klebsiella aerogenes.

Authors:  J E Fuglesang; T Bergan
Journal:  Infection       Date:  1984 Jan-Feb       Impact factor: 3.553

2.  Antibacterial activity and kill kinetics of amoxicillin-clavulanic acid combinations against Escherichia coli and Klebsiella aerogenes.

Authors:  J E Fuglesang; T Bergan
Journal:  Infection       Date:  1983 Nov-Dec       Impact factor: 3.553

3.  Inhibitory activity and bactericidal kinetics of mecillinam/ampicillin combinations against Enterobacteriaceae, Pseudomonas and Acinetobacter.

Authors:  J E Fuglesang; T Bergan; T Bielecki; A Naterstad; E Namork
Journal:  Infection       Date:  1981       Impact factor: 3.553
  3 in total

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