Adrenaline 1% combined with guanethidine 1% versus adrenaline 1%: a randomised prospective double-blind cross-over study.

The hypotensive effect of a combination of guanethidine 1% with adrenaline 1% was compared with adrenaline 1% alone on the eyes of 20 patients with ocular hypertension in a randomised double-blind cross-over trial. The patients received 8 weeks of treatment with each preparation. A significant increase in the hypotensive effect was found by adding guanethidine 1% to adrenaline 1%. This hypotensive effect was maintained over the 8-week period of the trial.

RCT Entities:   Population Interventions Outcomes