| Literature DB >> 7038048 |
K Dresdner, L A Barker, M Orlowski, S Wilk.
Abstract
The subcellular distribution of prolyl endopeptidase, and of cation-sensitive neutral endopeptidase, two enzymes actively metabolizing many neuropeptides, was determined in homogenates of rabbit brain. The subcellular distribution of both enzymes was more similar to lactate dehydrogenase, a cytoplasmic enzyme marker, than to choline acetyltransferase, a synaptosomal marker. Only 35% of the activity of these two neutral endopeptidases was found in the crude mitochondrial fraction (P2), the bulk of the remaining activity being associated with the high-speed supernatant. Prolyl endopeptidase and cation-sensitive neutral endopeptidase thus can be regarded as mainly cytoplasmic enzymes in the rabbit brain.Entities:
Mesh：
Substances：
Year: 1982 PMID： 7038048 DOI： 10.1111/j.1471-4159.1982.tb05362.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372