Literature DB >> 7037578

Mutagenic effects of allylisothiocyanate in Escherichia coli WP 67.

E Ríhová.   

Abstract

A mutagenic effect of allylisothiocyanate (AITC) on E. coli WP 67 (trp uvrA polA) was only found in a test with metabolic activation in vitro. Mixed function oxidases containing cytochrome P-450 are not responsible for the conversion of AITC to mutagenic products. Liver microsomal fractions of rat, mouse, chinese hamster, goat and monkey were used for in vitro metabolic activation. The mutagenic effect of AITC differed in individual animal species according to the protein content in the microsomal fraction. Allylamine (formed by hydrolysis of AITC) did not exhibit any mutagenic effect.

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Year:  1982        PMID： 7037578     DOI： 10.1007/bf02883833

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  13 in total

1.  Mutagenicity studies in microorganisms in vitro, with extracts of mammalian organs, and with the host-mediated-assay.

Authors:  G Mohn; J Ellenberger; D McGregor; H J Merker
Journal:  Mutat Res       Date:  1975-08       Impact factor: 2.433

2.  Predictive value of mutagenicity tests in chemical carcinogenesis.

Authors:  H Bartsch
Journal:  Mutat Res       Date:  1976-06       Impact factor: 2.433

3.  [Cytophotometrical measurements of the DNA content of the epidermis after unspecific, cocarcinogenic and carcinogenic stimuli].

Authors:  R Rohrbach; E Hecker; W Sandritter
Journal:  Z Krebsforsch       Date:  1968

4.  Differential induction and repair of ultraviolet damage leading to true revesions and external suppressor mutations of an ochre codon in Escherichia coli B-r WP2.

Authors:  B A Bridges; R E Dennis; R J Munson
Journal:  Genetics       Date:  1967-12       Impact factor: 4.562

5.  Comparative mutagenicity of N-nitrosamines in a semi-solid and in a liquid incubation system in the presence of rat or human tissue fractions.

Authors:  H Bartsch; A Camus; C Malaveille
Journal:  Mutat Res       Date:  1976-11       Impact factor: 2.433

6.  Correction method for estimating the number of reversions in bacteria.

Authors:  E Ríhová
Journal:  Folia Microbiol (Praha)       Date:  1981       Impact factor: 2.099

7.  Effects of cytochrome p-448 and p-450 inducers on microsomal dimethylnitrosamine demethylase activity and the capacity of isolated microsomes to activate dimethylnitrosamine to a mutagen.

Authors:  J B Guttenplan; F Hutterer; A J Garro
Journal:  Mutat Res       Date:  1976-06       Impact factor: 2.433

8.  [Relationships between chemical constitution and germicidial effect. 28. Preparation, antimicrobial and anthelminthic effect of diiosothiocyanates].

Authors:  H Teubner; W Weuffen; H Höppe
Journal:  Arch Exp Veterinarmed       Date:  1975

9.  Antifungal activity of isothiocyanates and related compounds. I. Naturally occurring isothiocyanates and their analogues.

Authors:  L Drobnica; M Zemanová; P Nemec; K Antos; P Kristián; A Stullerová; V Knoppová; P Nemec
Journal:  Appl Microbiol       Date:  1967-07

10.  Mutagen testing using TRP+ reversion in Escherichia coli.

Authors:  M H Green; W J Muriel
Journal:  Mutat Res       Date:  1976-02       Impact factor: 2.433
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  1 in total

1.  Antibacterial and mutagenic activities of new isothiocyanate derivatives.

Authors:  A Sovcíková; M Mikulásová; K Horáková; L Floch
Journal:  Folia Microbiol (Praha)       Date:  2001       Impact factor: 2.099
  1 in total

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