Literature DB >> 7036954

Retinol (vitamin A) as a modifier of 2-aminofluorene and 2-acetyl-aminofluorene mutagenesis in the Salmonella/microsome assay.

L Busk, U G Ahlborg.   

Abstract

Vitamin A (retinol)has been demonstrated to modify the mutagenic activity of the aromatic amines, 2-aminofluorene (2AF) and 2-acetylaminofluorene (2AAF) when added to the Ames Salmonella/mammalian microsome assay. Low amounts of retinol(2-20 micrograms/plate) increased the mutagenicity of both 2AF and 2AAF. At higher doses (50-150 micrograms/plates) the mutagenicity of 2AAF remained unchanged while the mutagenicity of 2AF gradually decreased. The present data do not support the hypothesis that retinol generally acts as an inhibitor of in vitro metabolic activation of procarcinogens.

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Year:  1982        PMID： 7036954     DOI： 10.1007/bf00332364

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  14 in total

1.  Vitamin A compounds and analogs as inhibitors of mixed-function oxidases that metabolize carcinogenic polycyclic hydrocarbons and other compounds.

Authors:  D L Hill; T W Shih
Journal:  Cancer Res       Date:  1974-03       Impact factor: 12.701

2.  Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.

Authors:  B N Ames; J Mccann; E Yamasaki
Journal:  Mutat Res       Date:  1975-12       Impact factor: 2.433

3.  Effects of structure of N-acyl-N-2-fluorenylhydroxylamines on arylhydroxamic acid acyltransferase, sulfotransferase, and deacylase activities, and on mutations in Salmonella typhimurium TA 1538.

Authors:  C E Weeks; W T Allaben; N M Tresp; S C Louie; E J Lazear; C M King
Journal:  Cancer Res       Date:  1980-04       Impact factor: 12.701

4.  In vitro metabolism and activation of carcinogenic aromatic amines by subcellular fractions of human liver.

Authors:  E Dybing; C von Bahr; T Aune; H Glaumann; D S Levitt; S S Thorgeirsson
Journal:  Cancer Res       Date:  1979-10       Impact factor: 12.701

5.  Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.

Authors:  A K Verma; R K Boutwell
Journal:  Cancer Res       Date:  1977-07       Impact factor: 12.701

Review 6.  Inhibition of carcinogenesis by retinoids.

Authors:  P Nettesheim
Journal:  Can Med Assoc J       Date:  1980-04-05       Impact factor: 8.262

7.  Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-(4-(5-Nitro-2-furyl)-2-thiazolyl)formamide.

Authors:  S M Cohen; J F Wittenberg; G T Bryan
Journal:  Cancer Res       Date:  1976-07       Impact factor: 12.701

8.  Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450.

Authors:  E F Johnson; D S Levitt; U Muller-Eberhard; S S Thorgeirsson
Journal:  Cancer Res       Date:  1980-12       Impact factor: 12.701

9.  Inhibition of 2-fluorenamine-induced mutagenesis in Salmonella typhimurium by vitamin A.

Authors:  M B Baird; L S Birnbaum
Journal:  J Natl Cancer Inst       Date:  1979-10       Impact factor: 13.506

10.  Metabolic activation of 2-acetylaminofluorene by isolated rat liver cells. Involvement of different metabolites causing DNA-repair and bacterial mutagenesis.

Authors:  R M Brouns; R P Bos; R von Doorn; P T Henderson
Journal:  Arch Toxicol       Date:  1980-05       Impact factor: 5.153
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  1 in total

1.  Effects of vitamin A on the metabolism and mutagenicity of 2AAF in vitro and on the covalent binding to rat liver DNA/RNA in vivo.

Authors:  L Rondahl; L Busk; U G Ahlborg; K Bergman
Journal:  Arch Toxicol       Date:  1985-08       Impact factor: 5.153
  1 in total

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