| Literature DB >> 7036619 |
P Tessari, A Meneghel, A Avogaro, E Duner, S Del Prato, M Tuzzato, A Tiengo.
Abstract
Mitochondrial glycerophosphate-acetyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats, A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10(-5) M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.Entities:
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Year: 1981 PMID： 7036619 DOI： 10.1007/bf02042820
Source DB: PubMed Journal: Acta Diabetol Lat ISSN： 0001-5563